{"id":"W3125152162","doi":"10.2139/ssrn.3403337","title":"Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6","year":2019,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Agence Nationale de la Recherche","keywords":"CRISPR; Allosteric regulation; Chemistry; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002660955,0.0003824069,0.0004806203,0.0001622759,0.0002468101,0.0006773866,0.0007450166,0.0005074557,0.005879025],"category_scores_gemma":[0.0003504707,0.0002300016,0.0003513269,0.0001456927,0.0004171461,0.0002314007,0.0004483566,0.001056325,0.002336964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000436911,"about_ca_system_score_gemma":0.0002702704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006333533,"about_ca_topic_score_gemma":0.0007991243,"domain_scores_codex":[0.9995529,0.00004454573,0.00004330336,0.0001278045,0.0001583455,0.00007314613],"domain_scores_gemma":[0.9998299,0.000034644,0.00004635861,0.00003086442,0.00002192392,0.00003629666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002084199,0.00003029354,0.00009095845,0.00005583351,0.000009234304,0.00004897766,0.00000871289,0.000139568,0.9962898,0.0004099975,0.0002629647,0.002445149],"study_design_scores_gemma":[0.00001785877,0.00006097975,0.0003307004,0.000003566834,0.00000448776,0.0001359737,0.000007721957,0.00173233,0.9949628,0.00006667941,0.002669575,0.000007163129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434065,0.002460063,0.02569597,0.0009431845,0.0006602306,0.00008664789,0.0009169424,0.002380884,0.0234496],"genre_scores_gemma":[0.9857966,0.0004208933,0.005627166,0.0001586943,0.00001994006,0.00001809249,0.0003195358,0.0001278992,0.007511136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005879025,"threshold_uncertainty_score":0.01966727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002629309536957879,"score_gpt":0.2406057163494559,"score_spread":0.237976406812498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}