{"id":"W3125200291","doi":"10.1261/rna.078660.120","title":"Activity and substrate specificity of <i>Candida</i>, <i>Aspergillus</i>, and <i>Coccidioides</i> Tpt1: essential tRNA splicing enzymes and potential antifungal targets","year":2021,"lang":"en","type":"article","venue":"RNA","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; NAD+ kinase; Biochemistry; RNA; Nicotinamide adenine dinucleotide; Ribitol; Candida albicans; Transfer RNA; RNA splicing; Enzyme; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378082,0.0005607869,0.0002504567,0.0002561505,0.00009322412,0.0004101952,0.0002602758,0.0003246589,0.001261631],"category_scores_gemma":[0.0004149665,0.000128889,0.000292089,0.0003858831,0.0001507269,0.0001761359,0.0001593108,0.0003731261,0.0005105617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003153837,"about_ca_system_score_gemma":0.0002210013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003273835,"about_ca_topic_score_gemma":0.00201503,"domain_scores_codex":[0.9997318,0.00003273175,0.00003800775,0.00006618241,0.00007397278,0.0000572316],"domain_scores_gemma":[0.9998187,0.00004032796,0.0000366011,0.00001917812,0.00004558778,0.00003968865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651413,0.00002094415,0.0004974409,0.00004267935,0.000005494436,0.00005111782,0.0000115528,0.0001321787,0.9968854,0.00005440218,0.00006057195,0.002073017],"study_design_scores_gemma":[0.000006633793,0.000122807,0.004664569,0.000005786637,0.00001259639,0.0003765268,0.00002492104,0.0006505257,0.992576,0.0000197593,0.001533787,0.000006177298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877813,0.004447932,0.003089396,0.0001199816,0.00005413786,0.00002971984,0.002020955,0.00008341997,0.002373209],"genre_scores_gemma":[0.9897944,0.001400897,0.002794479,0.0000491217,0.00001481874,0.00002088869,0.004064796,0.00003883645,0.001821688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003273835,"threshold_uncertainty_score":0.006509602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582812212871839,"score_gpt":0.2370102974021659,"score_spread":0.228427485189294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}