{"id":"W3125200291","doi":"10.1261/rna.078660.120","title":"Activity and substrate specificity of <i>Candida</i>, <i>Aspergillus</i>, and <i>Coccidioides</i> Tpt1: essential tRNA splicing enzymes and potential antifungal targets","year":2021,"lang":"en","type":"article","venue":"RNA","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Biology; NAD+ kinase; Biochemistry; RNA; Nicotinamide adenine dinucleotide; Ribitol; Candida albicans; Transfer RNA; RNA splicing; Enzyme; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001788106,0.00022195,0.0005421682,0.00007693234,0.0002583342,0.00005335099,0.00002718203,0.0001020894,0.00005190907],"category_scores_gemma":[0.00005784723,0.0001991291,0.00008152638,0.00017713,0.0002760032,0.0001528298,0.000123835,0.0002422933,0.000001203677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001926157,"about_ca_system_score_gemma":0.0000590651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510731,"about_ca_topic_score_gemma":0.0001336363,"domain_scores_codex":[0.9987981,0.00004488518,0.0002682816,0.0004184415,0.0002015131,0.0002687186],"domain_scores_gemma":[0.9993274,0.00007345719,0.0001061149,0.0001911267,0.0001450891,0.0001568227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002425223,0.0001786808,0.03908667,0.0002777862,0.0002016144,0.000196963,0.0002251084,0.000004831917,0.9555103,0.0004183367,0.0005213198,0.0031359],"study_design_scores_gemma":[0.001380886,0.0002067406,0.3015305,0.0001354596,0.0002504963,0.000411442,0.0002533788,0.0002569073,0.6946992,0.0000935493,0.00055989,0.0002215776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989748,0.006871772,0.0002346048,0.0004344964,0.0002911856,0.0001646785,0.00004484933,0.00003535578,0.002175054],"genre_scores_gemma":[0.9942933,0.004643142,0.000309393,0.00009077724,0.0002522303,0.000003762556,0.000007888259,0.0000202197,0.0003793162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2624438,"threshold_uncertainty_score":0.8120248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582812212871839,"score_gpt":0.2370102974021659,"score_spread":0.228427485189294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}