{"id":"W3125206715","doi":"10.1038/s41551-020-00671-z","title":"In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA","year":2021,"lang":"en","type":"article","venue":"Nature Biomedical Engineering","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Novartis Stiftung für Medizinisch-Biologische Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Cytidine; RNA; RNA editing; Biology; Cytidine deaminase; Transcriptome; DNA; Genome editing; Molecular biology; Base pair; Genetics; Computational biology; Genome; Gene; Gene expression; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152065,0.0001222275,0.0001753094,0.0001227334,0.00001184973,0.000007863767,0.00006716419,0.0002677069,0.00002323817],"category_scores_gemma":[0.0005266056,0.0001295588,0.0000342873,0.0002653892,0.00002882483,0.00000607784,0.00007022094,0.000263207,2.234454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001664404,"about_ca_system_score_gemma":0.00004933129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001047924,"about_ca_topic_score_gemma":0.00002533383,"domain_scores_codex":[0.9991895,0.00001140143,0.0002236537,0.0002298581,0.0001287803,0.0002167829],"domain_scores_gemma":[0.99969,0.00003023157,0.00002453922,0.0001277081,0.00004009037,0.00008745437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006898439,0.00002981262,0.00138959,0.0001115884,0.00001318751,0.00003387382,0.00004497801,0.003347798,0.9945433,0.00002281687,0.00006600199,0.0003901502],"study_design_scores_gemma":[0.0006428512,0.00004185176,0.001427306,0.0001235591,0.000006493945,0.00003092609,0.00005330889,0.03854417,0.952958,0.00001300445,0.006014798,0.0001437249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856961,0.005707312,0.008007693,0.0001441902,0.000261525,0.00007935656,0.00002328211,0.00001243674,0.00006812348],"genre_scores_gemma":[0.9891886,0.0001252372,0.01035339,0.00004062899,0.0001916805,0.00001147073,0.00003632422,0.00001858,0.0000340519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04158529,"threshold_uncertainty_score":0.5283255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00261662799132924,"score_gpt":0.2502982781379663,"score_spread":0.2476816501466371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}