{"id":"W3125206715","doi":"10.1038/s41551-020-00671-z","title":"In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA","year":2021,"lang":"en","type":"article","venue":"Nature Biomedical Engineering","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Novartis Stiftung für Medizinisch-Biologische Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Cytidine; RNA; RNA editing; Biology; Cytidine deaminase; Transcriptome; DNA; Genome editing; Molecular biology; Base pair; Genetics; Computational biology; Genome; Gene; Gene expression; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002729303,0.0002872958,0.0002709414,0.000179459,0.0001571502,0.000409547,0.0002374443,0.000326358,0.00214337],"category_scores_gemma":[0.0002159575,0.0001752277,0.0001685108,0.0001137252,0.0002870292,0.0001481735,0.0001750844,0.0005663648,0.0006270345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245081,"about_ca_system_score_gemma":0.0002707152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001076374,"about_ca_topic_score_gemma":0.001517804,"domain_scores_codex":[0.9997504,0.00005724572,0.00001971966,0.000063251,0.00005985938,0.00004956841],"domain_scores_gemma":[0.9997028,0.00008104482,0.00005345238,0.00006345764,0.00003105398,0.0000680564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001872269,0.00001928883,0.00006797075,0.00001182432,0.000003471211,0.00005154739,0.0000103212,0.00006065553,0.9986236,0.0001407494,0.00002785933,0.000795415],"study_design_scores_gemma":[0.000009812661,0.00007917092,0.0003019904,7.776232e-7,0.000003959988,0.00005890158,0.000005331451,0.0002354044,0.998813,0.00002176941,0.0004681393,0.000001784376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784879,0.0004000872,0.01372644,0.0001306677,0.0001095568,0.00006717285,0.0005724839,0.0003708224,0.006134898],"genre_scores_gemma":[0.9903019,0.000128795,0.003092449,0.00003619367,0.00001022671,0.00002175475,0.0002901062,0.00009439311,0.006024127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00214337,"threshold_uncertainty_score":0.00717032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00261662799132924,"score_gpt":0.2502982781379663,"score_spread":0.2476816501466371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}