{"id":"W3125242144","doi":"10.1002/onco.13692","title":"Selinexor, a First in Class, Nuclear Export Inhibitor for the Treatment of Advanced Malignant Peripheral Nerve Sheath Tumor","year":2021,"lang":"en","type":"article","venue":"The Oncologist","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Malignant peripheral nerve sheath tumor; Peripheral; Peripheral nerve; Nuclear export signal; Cancer research; Surgery; Pathology; Internal medicine; Anatomy; Cell nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746204,0.0001579464,0.0004144509,0.00002169814,0.0001404223,0.00001781055,0.0001047023,0.00004613843,0.0001015273],"category_scores_gemma":[0.0001252463,0.00007670195,0.0002068235,0.0001544376,0.0001740043,0.0000315639,0.00003665192,0.00007986934,0.000004596369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783105,"about_ca_system_score_gemma":0.0001838926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008874534,"about_ca_topic_score_gemma":0.0002567018,"domain_scores_codex":[0.9989243,0.00006105875,0.0003843153,0.0002448162,0.0001494696,0.0002360123],"domain_scores_gemma":[0.9989269,0.0003748811,0.0001240902,0.0004379442,0.00008204785,0.00005409545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02881256,0.03016004,0.09005269,0.001691819,0.001319065,0.02171777,0.01914678,0.002000965,0.6046832,0.0134834,0.1085299,0.07840189],"study_design_scores_gemma":[0.01307536,0.01516729,0.07023396,0.0004131228,0.0004651687,0.001494517,0.00899928,0.002970485,0.068875,0.0001266494,0.8177863,0.0003928731],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869201,0.001541596,0.000005505316,0.009680277,0.0002367565,0.000873241,0.00004178676,0.00002965146,0.0006710759],"genre_scores_gemma":[0.9965176,0.0003661081,0.000826879,0.0005375923,0.0002270541,0.0002041485,0.00001626325,0.00002724313,0.001277091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7092564,"threshold_uncertainty_score":0.3127815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03363152014919998,"score_gpt":0.2939988963940334,"score_spread":0.2603673762448334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}