{"id":"W3125299634","doi":"10.3390/md19020051","title":"Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39","year":2021,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Helmholtz-Zentrum Dresden-Rossendorf; Crohn's and Colitis Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Adenosine; Biochemistry; Extracellular; Purinergic receptor; Chemistry; Phosphodiesterase; Nucleoside; Adenosine triphosphate; Apyrase; Pharmacology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008775494,0.0002963999,0.0001468929,0.0001273528,0.00006585246,0.000111265,0.00006929356,0.000148886,0.0008929018],"category_scores_gemma":[0.00007683606,0.00006368844,0.0001218479,0.00009289242,0.00009944323,0.00006456486,0.0001250077,0.0002530417,0.0001723348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007511013,"about_ca_system_score_gemma":0.000103232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001708904,"about_ca_topic_score_gemma":0.0005063573,"domain_scores_codex":[0.9999267,0.00001806505,0.000005897555,0.00001088932,0.00002718156,0.00001131124],"domain_scores_gemma":[0.9999551,0.00001268367,0.00001109895,0.000004362756,0.000005173989,0.00001162563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006209507,0.00002289571,0.0000957996,0.000033833,0.000004213153,0.0000187398,0.000005515505,0.00004640352,0.9971346,0.00003019765,0.00001696719,0.002528889],"study_design_scores_gemma":[0.00001542047,0.0006563948,0.002542559,0.000005220547,0.00001125778,0.0001487363,0.00000963155,0.0002304414,0.9940234,0.00002217012,0.002332569,0.000002194124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878323,0.005450774,0.004385187,0.00008177397,0.00004628785,0.00005435593,0.000226706,0.00002861437,0.001893869],"genre_scores_gemma":[0.991311,0.002689205,0.003305236,0.00004343928,0.00002018069,0.00004599883,0.0004078052,0.000006484793,0.002170698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008929018,"threshold_uncertainty_score":0.002987087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007014023996782632,"score_gpt":0.2237768831285435,"score_spread":0.2167628591317609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}