{"id":"W3125299634","doi":"10.3390/md19020051","title":"Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39","year":2021,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Helmholtz-Zentrum Dresden-Rossendorf; Crohn's and Colitis Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Adenosine; Biochemistry; Extracellular; Purinergic receptor; Chemistry; Phosphodiesterase; Nucleoside; Adenosine triphosphate; Apyrase; Pharmacology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006715915,0.0001867156,0.0002427161,0.00004493356,0.0001164614,0.00004216684,0.00009010713,0.0001128573,0.0001439573],"category_scores_gemma":[0.00005182785,0.0001876786,0.00009661738,0.0001084545,0.00008713437,0.000005751337,0.0004599193,0.000100124,0.000002600362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008286772,"about_ca_system_score_gemma":0.00004342328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080677,"about_ca_topic_score_gemma":0.00006104389,"domain_scores_codex":[0.9989215,0.00004792493,0.0002905541,0.0003894338,0.0001346252,0.0002159868],"domain_scores_gemma":[0.9993884,0.00002246663,0.000141407,0.0002737028,0.00008865658,0.00008536318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003733163,0.0000769071,0.045784,0.00003011579,0.000109797,0.00006509783,0.0002061482,0.0000307967,0.9510093,0.00002830994,0.0012617,0.001360494],"study_design_scores_gemma":[0.0007198373,0.00008536615,0.01935301,0.00005136102,0.0000541895,0.00002146082,0.0004727283,0.00004803144,0.9770225,0.0001263912,0.001806393,0.0002387713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968668,0.002106994,0.00002042709,0.0002330434,0.00008205473,0.00006546507,0.00004685712,0.00001966287,0.0005586984],"genre_scores_gemma":[0.9981242,0.0001035239,0.0001926607,0.0001796912,0.0003424808,0.000004519738,0.0004168445,0.00002987253,0.0006061629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02643099,"threshold_uncertainty_score":0.7653311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007014023996782632,"score_gpt":0.2237768831285435,"score_spread":0.2167628591317609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}