{"id":"W3125315716","doi":"10.1016/j.microc.2021.105964","title":"Green analytical method for the determination of sofosbuvir, ledipasvir, ribavirin and complex silymarin flavonoids simultaneously in biological fluids","year":2021,"lang":"en","type":"article","venue":"Microchemical Journal","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Ledipasvir; Sofosbuvir; Formic acid; Ribavirin; Cirrhosis; Chemistry; Chromatography; Hepatitis C virus; Medicine; Gastroenterology; Virus; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561395,0.0001889782,0.0003682855,0.00009273909,0.0002575815,0.00003437229,0.0002289274,0.0005019303,0.0002410643],"category_scores_gemma":[0.0006019727,0.0001450764,0.0001641601,0.0002346298,0.0002550461,0.00007059498,0.0001306531,0.001280485,0.000004250468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009765806,"about_ca_system_score_gemma":0.00009549229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002940206,"about_ca_topic_score_gemma":0.0000409728,"domain_scores_codex":[0.997991,0.0006363672,0.0005854233,0.0002845891,0.0001290982,0.0003735224],"domain_scores_gemma":[0.9970221,0.002342666,0.000152703,0.0001159277,0.0002045748,0.0001620435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003828911,0.0002077894,0.00240975,0.0000371335,0.00006067785,0.0000498833,0.0002478471,0.00004659329,0.8651062,0.0001647667,0.0002198373,0.1310666],"study_design_scores_gemma":[0.003068269,0.0002278402,0.002744417,0.00003383717,0.0001763255,0.00136783,0.0002695769,0.1420193,0.811316,0.003875608,0.03459789,0.0003030592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9378088,0.0005353438,0.0581556,0.002571721,0.0003109481,0.0003745516,0.00003846962,0.00001906633,0.0001855508],"genre_scores_gemma":[0.9846935,0.000351893,0.01313481,0.001200292,0.0003638229,0.00002680868,0.00002303696,0.00001580353,0.00019007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1419727,"threshold_uncertainty_score":0.5916042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1805767430354888,"score_gpt":0.456834320522142,"score_spread":0.2762575774866531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}