{"id":"W3125331816","doi":"10.20517/2574-1209.2020.71","title":"The local effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) on the inflammatory atheroma: beyond LDL cholesterol lowering","year":2021,"lang":"en","type":"article","venue":"Vessel Plus","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"PCSK9; Kexin; Proprotein convertase; LDL receptor; Atheroma; Cholesterol; Proprotein Convertases; Subtilisin; Evolocumab; Lipoprotein; Internal medicine; Medicine; Endocrinology; Cancer research; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693097,0.0002669766,0.0004520984,0.0003338515,0.000124295,0.000418558,0.0001640285,0.0003546331,0.001183083],"category_scores_gemma":[0.0001863689,0.00006307425,0.0002542793,0.0002424431,0.0002862137,0.0003793954,0.0002901349,0.0006036386,0.0002745363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186798,"about_ca_system_score_gemma":0.0002025004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002737024,"about_ca_topic_score_gemma":0.0005799847,"domain_scores_codex":[0.999913,0.00001693818,0.00001103392,0.00001620172,0.00002671019,0.00001607777],"domain_scores_gemma":[0.9999161,0.00003189541,0.00001782042,0.000003032644,0.00001990022,0.00001123695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006588105,0.0001045421,0.001790422,0.01018935,0.0001659828,0.002230598,0.0002893072,0.0007004918,0.2820554,0.009464854,0.006246766,0.6861035],"study_design_scores_gemma":[0.0001059148,0.002328919,0.02630354,0.002441241,0.0006218325,0.013866,0.0006936335,0.001193465,0.252468,0.009232804,0.6906497,0.00009493199],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02453704,0.9664626,0.002345754,0.001598219,0.0005323158,0.00001244114,0.00006223939,0.00002924511,0.004420178],"genre_scores_gemma":[0.08789236,0.9050393,0.001509165,0.0006078205,0.001030595,0.00001437377,0.0000804096,0.000008180274,0.003817774],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001183083,"threshold_uncertainty_score":0.003957868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008392995686062306,"score_gpt":0.2294386110200728,"score_spread":0.2210456153340105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}