{"id":"W3125345026","doi":"10.1002/cpt.2173","title":"StellarPGx: A Nextflow Pipeline for Calling Star Alleles in Cytochrome P450 Genes","year":2021,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Manitoba","funders":"GlaxoSmithKline foundation; National Research Foundation","keywords":"Genotyping; Genetics; Computational biology; 1000 Genomes Project; Biology; Haplotype; Pharmacogenomics; Genome; Gene; Allele; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002220591,0.002029513,0.001009934,0.001310027,0.0009877759,0.001623013,0.001753673,0.0008596579,0.01331515],"category_scores_gemma":[0.003072428,0.001155104,0.00168887,0.0007908843,0.0004781605,0.001589698,0.001817909,0.002063722,0.003743449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001096171,"about_ca_system_score_gemma":0.002288648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008101065,"about_ca_topic_score_gemma":0.006876069,"domain_scores_codex":[0.9992955,0.0001258832,0.00006112124,0.0002608435,0.0001680785,0.00008863175],"domain_scores_gemma":[0.999209,0.000394534,0.00007422049,0.000115516,0.0001381365,0.00006863775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004361971,0.0006340565,0.02770226,0.002333086,0.001412002,0.001238245,0.002132208,0.05679408,0.133629,0.01535646,0.2686207,0.4857859],"study_design_scores_gemma":[0.0009506027,0.000386301,0.01588587,0.0001497961,0.0002651981,0.000419671,0.0001692319,0.7316329,0.09127318,0.03409235,0.1244149,0.0003600045],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"software","genre_scores_codex":[0.02375554,0.0005793304,0.5915291,0.0004984169,0.0001809514,0.000475188,0.0232174,0.3571257,0.002638457],"genre_scores_gemma":[0.1406633,0.0006493386,0.7372009,0.001252274,0.000112339,0.002453076,0.08867635,0.02205827,0.006934114],"genre_candidate":"software","genre_consensus":null,"teacher_disagreement_score":0.01331515,"threshold_uncertainty_score":0.04454356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.342208073002502,"score_gpt":0.5455487412779744,"score_spread":0.2033406682754724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}