{"id":"W3125370141","doi":"10.3389/fimmu.2020.621774","title":"Peptide-MHC-Based Nanomedicines for the Treatment of Autoimmunity: Engineering, Mechanisms, and Diseases","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Praespero; Multiple Sclerosis Society; Crohn's and Colitis Foundation of Canada; Diabetes Canada; Multiple Sclerosis Society of Canada; Crohn's and Colitis Foundation","keywords":"Autoimmunity; Major histocompatibility complex; Immunology; Bystander effect; Effector; Immune system; Epitope; Disease; Biology; Autoimmune disease; Computational biology; Medicine; Antigen; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000497923,0.0007642679,0.0007870304,0.001257732,0.0001898477,0.0006810604,0.0006440124,0.0009112417,0.002081641],"category_scores_gemma":[0.0003588547,0.0002415718,0.0002901028,0.001117812,0.0003706437,0.001024075,0.0005079645,0.001748604,0.001553575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004976039,"about_ca_system_score_gemma":0.0006274368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004018172,"about_ca_topic_score_gemma":0.0008162078,"domain_scores_codex":[0.9998683,0.00002223641,0.00001222378,0.00001835397,0.000059704,0.00001913296],"domain_scores_gemma":[0.9998846,0.00004530426,0.00001869227,0.000004550728,0.00002975779,0.0000170136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009203054,0.0001123265,0.00009239479,0.0120008,0.00005541147,0.000176647,0.00005321668,0.0006579997,0.009921192,0.007818012,0.03153972,0.9374802],"study_design_scores_gemma":[0.00001450144,0.0001526368,0.0003465272,0.001281702,0.00003790433,0.0007665434,0.00002602824,0.0001484942,0.001758273,0.002114768,0.9933404,0.00001222302],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002299765,0.9977422,0.0002942688,0.0002288149,0.0003034854,0.000007045998,0.00001353724,0.00001077212,0.001169995],"genre_scores_gemma":[0.001216786,0.9971055,0.0002886772,0.0001872792,0.0001941923,0.000009883174,0.00002428138,0.000001863167,0.000971493],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002081641,"threshold_uncertainty_score":0.00696373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627688596359687,"score_gpt":0.2629055445891812,"score_spread":0.2466286586255843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}