{"id":"W3125412170","doi":"10.1242/dev.195495","title":"SMAD2 promotes myogenin expression and terminal myogenic differentiation","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Wellcome Trust; British Heart Foundation; King Saud University; Government of Ontario","keywords":"Myogenin; Myogenesis; Biology; Myostatin; Myogenic regulatory factors; Myocyte; Cell biology; Smad2 Protein; C2C12; Transforming growth factor; MyoD; Cellular differentiation; Transcription factor; Signal transduction; Transforming growth factor beta; Skeletal muscle; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004004142,0.00008282976,0.00006628611,0.00001380387,0.00008625313,0.00001061064,0.00004188587,0.00007504646,0.0000489772],"category_scores_gemma":[0.00002372243,0.0000768042,0.00002127096,0.0000261427,0.00002313358,0.000002075386,0.0001042836,0.00003366282,0.000006091196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004669243,"about_ca_system_score_gemma":0.00007964916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.050036e-7,"about_ca_topic_score_gemma":0.00000832575,"domain_scores_codex":[0.9994625,0.00003193221,0.0001024164,0.0002322052,0.00005326844,0.0001176564],"domain_scores_gemma":[0.9997871,0.000003879293,0.00002959916,0.0001075614,0.00003102167,0.00004085678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002991145,0.00004726558,0.003986087,0.00001539225,0.00002104595,0.000003052325,0.0001231337,7.679942e-7,0.9824933,0.00001556816,0.000317116,0.01294733],"study_design_scores_gemma":[0.000283697,0.00002941987,0.1297671,0.00001058993,0.000004545069,0.00001050939,0.00004762546,0.000006114048,0.8639153,0.00009493138,0.0057238,0.0001063541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982198,0.0007102496,0.000646969,0.00006114042,0.00006326991,0.00005713227,0.000001501646,0.000006969503,0.0002329581],"genre_scores_gemma":[0.9968177,0.00007939315,0.002168169,0.0001363127,0.00003627176,0.00002367202,0.0002553263,0.000006730162,0.0004764296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1257811,"threshold_uncertainty_score":0.3131984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008040243184413359,"score_gpt":0.2220972753370725,"score_spread":0.2140570321526592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}