{"id":"W3125412170","doi":"10.1242/dev.195495","title":"SMAD2 promotes myogenin expression and terminal myogenic differentiation","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Wellcome Trust; British Heart Foundation; King Saud University; Government of Ontario","keywords":"Myogenin; Myogenesis; Biology; Myostatin; Myogenic regulatory factors; Myocyte; Cell biology; Smad2 Protein; C2C12; Transforming growth factor; MyoD; Cellular differentiation; Transcription factor; Signal transduction; Transforming growth factor beta; Skeletal muscle; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806887,0.0003805798,0.0002076731,0.0003127312,0.0001737665,0.0002705323,0.0001220075,0.0002327654,0.002824221],"category_scores_gemma":[0.00007745401,0.0001788531,0.0002712552,0.0001324816,0.0001892334,0.0001396842,0.0003065066,0.0005156234,0.0007875286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157872,"about_ca_system_score_gemma":0.0001850266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003048713,"about_ca_topic_score_gemma":0.0006424409,"domain_scores_codex":[0.9998726,0.0000206505,0.000008085811,0.0000252136,0.00004158658,0.00003190434],"domain_scores_gemma":[0.9998827,0.00001307841,0.00002521011,0.000009043628,0.00001735515,0.00005251608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000753412,0.00001289327,0.0001011563,0.00003232696,0.000003010442,0.0000323637,0.00000508024,0.00002094218,0.9992442,0.00007792546,0.00005599727,0.0003389084],"study_design_scores_gemma":[0.00002633306,0.00020511,0.008223905,0.00001160892,0.00001423234,0.0002644333,0.00003393832,0.0006875262,0.9846374,0.00006886066,0.005822239,0.00000437967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821358,0.00393676,0.005949335,0.0002761169,0.0001423041,0.00004649414,0.0009859754,0.0001711795,0.006356178],"genre_scores_gemma":[0.9843174,0.001262271,0.001922,0.0001317896,0.00004150433,0.00003704739,0.001077971,0.00004130531,0.01116866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002824221,"threshold_uncertainty_score":0.009447932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008040243184413359,"score_gpt":0.2220972753370725,"score_spread":0.2140570321526592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}