{"id":"W3125468057","doi":"10.1016/j.dci.2021.104021","title":"Do ectothermic vertebrates have a home in which to affinity mature their antibody responses?","year":2021,"lang":"en","type":"review","venue":"Developmental & Comparative Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Somatic hypermutation; Biology; Ectotherm; Cytidine deaminase; Affinity maturation; Activation-induced (cytidine) deaminase; Germinal center; Zebrafish; Antibody; Genetics; Gene; Evolutionary biology; Cell biology; Zoology; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.0006388613,0.00173248,0.005790323,0.001437024,0.0004612331,0.0001063647,0.001694749,0.002425354,0.002672062],"category_scores_gemma":[0.0001749652,0.001447816,0.000577234,0.001754776,0.0006921758,0.0001756988,0.001416502,0.003207542,0.007026315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008730956,"about_ca_system_score_gemma":0.001996074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001499182,"about_ca_topic_score_gemma":0.0006922343,"domain_scores_codex":[0.9906103,0.003794477,0.001888337,0.001920765,0.00009908966,0.001687022],"domain_scores_gemma":[0.9966469,0.001272225,0.000697078,0.001017679,0.0002877172,0.00007834738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002307166,0.003305776,0.001466176,0.002227283,0.01222564,0.0008530803,0.02137044,0.000003204467,0.7228047,0.001547775,0.008829774,0.223059],"study_design_scores_gemma":[0.001868582,0.000433106,0.001002159,0.004538264,0.0001839567,0.002067114,0.002876025,3.014301e-7,0.01002918,0.00006142617,0.9752104,0.001729514],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07510922,0.9188395,0.00001352985,0.00009721921,0.002132493,0.001674663,0.0003571083,0.0001645926,0.001611679],"genre_scores_gemma":[0.04670265,0.9433896,0.0002974594,0.0002233574,0.00005211112,0.0006388709,0.003820121,0.0001536341,0.004722199],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9663806,"threshold_uncertainty_score":0.9995421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0559825080369556,"score_gpt":0.3393337120089832,"score_spread":0.2833512039720276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}