{"id":"W3125468057","doi":"10.1016/j.dci.2021.104021","title":"Do ectothermic vertebrates have a home in which to affinity mature their antibody responses?","year":2021,"lang":"en","type":"review","venue":"Developmental & Comparative Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Somatic hypermutation; Biology; Ectotherm; Cytidine deaminase; Affinity maturation; Activation-induced (cytidine) deaminase; Germinal center; Zebrafish; Antibody; Genetics; Gene; Evolutionary biology; Cell biology; Zoology; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000483802,0.0005339165,0.0007655811,0.0004950475,0.0001658968,0.0007468047,0.0005521131,0.001085546,0.002548026],"category_scores_gemma":[0.0004672646,0.0001613691,0.0001481786,0.0005975543,0.0006727932,0.001399429,0.0005598136,0.001202213,0.001615012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005186598,"about_ca_system_score_gemma":0.0009283512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008799256,"about_ca_topic_score_gemma":0.002210621,"domain_scores_codex":[0.9999254,0.00001020783,0.000007956645,0.00001644056,0.00002584982,0.00001407672],"domain_scores_gemma":[0.9998535,0.0000482612,0.00002760706,0.00000613067,0.0000396028,0.00002481721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009145194,0.00001235085,0.0003036102,0.004200439,0.00002760715,0.0001223059,0.00003697294,0.000135575,0.003903345,0.00526243,0.0387209,0.9471829],"study_design_scores_gemma":[0.000009168958,0.00004466844,0.001475865,0.001204252,0.00004807357,0.0004899465,0.0000588018,0.00005018703,0.0006118319,0.003175096,0.9928244,0.000007695983],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002160852,0.9958038,0.0003884785,0.001019183,0.00093828,0.000002223353,0.00002261617,0.0000115587,0.001597791],"genre_scores_gemma":[0.001737422,0.9937489,0.0003598342,0.0008436169,0.0009350236,0.000006505591,0.00004935512,0.000002830699,0.002316504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002548026,"threshold_uncertainty_score":0.00852406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0559825080369556,"score_gpt":0.3393337120089832,"score_spread":0.2833512039720276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}