{"id":"W3125531284","doi":"10.1159/000512720","title":"Expanding the Horizons of mTOR Inhibitors for Treating Subependymal Giant Cell Astrocytomas with Obstructive Hydrocephalus","year":2021,"lang":"en","type":"article","venue":"Pediatric Neurosurgery","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Subependymal zone; Subependymal giant cell astrocytoma; Hydrocephalus; Discovery and development of mTOR inhibitors; Obstructive hydrocephalus; PI3K/AKT/mTOR pathway; Pathology; Cancer research; Radiology; Astrocytoma; Glioma; Signal transduction; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002646609,0.0007075765,0.001507331,0.001334044,0.0004689957,0.002079884,0.001874828,0.00517944,0.003247656],"category_scores_gemma":[0.0106786,0.0003467289,0.0007195069,0.0006613803,0.001257476,0.003223811,0.0007670186,0.009350231,0.002568757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006488969,"about_ca_system_score_gemma":0.0007544423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003843934,"about_ca_topic_score_gemma":0.001226943,"domain_scores_codex":[0.9987139,0.0002814475,0.0002295164,0.0001490874,0.0005242276,0.0001018384],"domain_scores_gemma":[0.9928843,0.003569683,0.0007491678,0.0001201864,0.001934942,0.0007416382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0002578424,0.00005878693,0.0005495378,0.002316562,0.0001137442,0.00169506,0.000151729,0.0001895889,0.0009474728,0.001966849,0.8367382,0.1550147],"study_design_scores_gemma":[0.00008305346,0.0001560677,0.0009641729,0.001106611,0.0001325148,0.003960006,0.0001165523,0.0004898807,0.0004910334,0.001239356,0.9912274,0.0000333048],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"editorial","genre_gemma":"empirical","genre_scores_codex":[0.001517479,0.1809585,0.001568228,0.3517782,0.459304,0.00003295473,0.0001724786,0.0001280601,0.00454012],"genre_scores_gemma":[0.005495774,0.08262958,0.0007207622,0.09898207,0.8082528,0.00002313204,0.00005501637,0.0000633806,0.003777547],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00517944,"threshold_uncertainty_score":0.01399678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02747277243372424,"score_gpt":0.2688862169267884,"score_spread":0.2414134444930642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}