{"id":"W3125587045","doi":"10.1101/2021.01.27.428341","title":"Generation of a New Frizzled 2 Flox Mouse Model to Clarify Its Role in Development","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Rochester; University of Toronto; Johns Hopkins University; University of Pennsylvania","keywords":"Frizzled; Biology; Knockout mouse; Phenotype; Gene knockout; Wnt signaling pathway; Conditional gene knockout; Gene targeting; Null allele; Computational biology; Gene; Homologous recombination; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005619464,0.0009123755,0.0006190963,0.001534197,0.0004877086,0.0005293119,0.0007104337,0.001185321,0.004296151],"category_scores_gemma":[0.0002361374,0.0003739045,0.0006820393,0.0003059058,0.0005884842,0.0006557347,0.0005537339,0.001743903,0.001356899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005041615,"about_ca_system_score_gemma":0.0004424989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006771658,"about_ca_topic_score_gemma":0.001091854,"domain_scores_codex":[0.9996973,0.00003174873,0.00003961811,0.00009568442,0.0000899021,0.00004580099],"domain_scores_gemma":[0.999698,0.00004177938,0.00007449577,0.00004864185,0.00003763482,0.00009937929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009600208,0.00009534015,0.0002163106,0.00006942575,0.00001091049,0.0002698457,0.00004825203,0.0000983935,0.9946129,0.001379902,0.0003655357,0.002737205],"study_design_scores_gemma":[0.0001586659,0.001079037,0.003606332,0.00008695204,0.0001411685,0.0033234,0.00008112075,0.00205037,0.9421614,0.0005623003,0.04670881,0.00004040138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8109783,0.006036646,0.1598879,0.001899376,0.0009302926,0.001458823,0.006975997,0.002049203,0.009783402],"genre_scores_gemma":[0.784106,0.007285691,0.1436585,0.0011537,0.0002017349,0.003511991,0.009640285,0.0008734349,0.0495687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004296151,"threshold_uncertainty_score":0.01437205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0308206382419002,"score_gpt":0.2407103248740166,"score_spread":0.2098896866321164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}