{"id":"W3125588754","doi":"10.1007/s13555-021-00487-y","title":"Dupilumab Maintains Long-Term Disease Control in Adults with Moderate-to-Severe Atopic Dermatitis as Measured by Well-Controlled Weeks: Results From the LIBERTY AD CHRONOS Clinical Trial","year":2021,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Windsor Clinical Research","funders":"Sanofi Genzyme; LEO Pharma; Astellas Pharma; Kyowa Hakko Kirin; Dermira; Sun Pharma; Regeneron Pharmaceuticals; Celgene; Genentech; Valeant Pharmaceuticals International; Sanofi; GlaxoSmithKline; Australian Wool Innovation; Amgen; Pfizer; Galderma; Eli Lilly and Company; Bristol-Myers Squibb; Astellas Pharma US","keywords":"Atopic dermatitis; Dupilumab; Medicine; Placebo; Disease; Clinical trial; Randomized controlled trial; Dermatology; Internal medicine; Pediatrics; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003044226,0.0005696421,0.001584071,0.0002392882,0.0002558571,0.0009006226,0.0003138004,0.0006975968,0.001335174],"category_scores_gemma":[0.002186531,0.0001581556,0.001725459,0.0003346156,0.0004495204,0.0007249888,0.0003030335,0.001180441,0.0001498097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003914433,"about_ca_system_score_gemma":0.0003246308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000468751,"about_ca_topic_score_gemma":0.001209671,"domain_scores_codex":[0.9989088,0.0005939564,0.0001096026,0.0001262594,0.0001332875,0.0001282617],"domain_scores_gemma":[0.9983944,0.0005734783,0.0005403206,0.0001152989,0.00007432162,0.0003022213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8567112,0.003575135,0.03964722,0.001362787,0.007416628,0.000146064,0.000168189,0.0008729731,0.007393152,0.0002259862,0.001066665,0.08141392],"study_design_scores_gemma":[0.424109,0.2779283,0.2758441,0.0002624694,0.01006737,0.0006542267,0.0002091267,0.002398596,0.003309988,0.0004687906,0.00464801,0.0001001745],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897968,0.008391836,0.0001831847,0.0001401408,0.00006007761,0.000150672,0.0004939854,0.0000148677,0.0007684297],"genre_scores_gemma":[0.9976241,0.001090078,0.0002069965,0.0002000124,0.00006569826,0.00009336233,0.0004825411,0.000003787934,0.0002334434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044226,"threshold_uncertainty_score":0.01609963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558212892593266,"score_gpt":0.2849635979488684,"score_spread":0.2693814690229357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}