{"id":"W3125591359","doi":"10.1101/2021.01.19.427307","title":"Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Alberta; University of Calgary; University of Lethbridge","funders":"","keywords":"cccDNA; Hepatitis B virus; Virology; Biology; Hepatitis B virus PRE beta; Molecular biology; Virus; Hepatitis B virus DNA polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351669,0.0001372858,0.00009446081,0.0002578839,0.0001456131,0.000144614,0.0001197484,0.0002010672,0.0006857148],"category_scores_gemma":[0.0002728704,0.00008792472,0.0001181007,0.000110529,0.0001233435,0.0001044511,0.0000962219,0.0002691253,0.0003760095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125373,"about_ca_system_score_gemma":0.0001591564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005963618,"about_ca_topic_score_gemma":0.0006407474,"domain_scores_codex":[0.9999325,0.00001248517,0.000005212781,0.00001824878,0.00002200518,0.000009474191],"domain_scores_gemma":[0.9998608,0.00003122509,0.00002887981,0.00001255067,0.00003350842,0.00003313847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002223194,0.00001863812,0.0006022444,0.00002263606,0.000002588346,0.00004026161,0.00002800337,0.00006021361,0.9979358,0.00004241181,0.00002348557,0.001201561],"study_design_scores_gemma":[0.00001490951,0.0004543429,0.02713509,0.00002061909,0.00002128448,0.001076994,0.0001159597,0.003784675,0.9620262,0.0002033698,0.005135008,0.00001148339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990754,0.0007832759,0.007088064,0.00008381662,0.00001383046,0.00004325774,0.0004102181,0.00003255167,0.0007910599],"genre_scores_gemma":[0.9875705,0.0004651254,0.008123392,0.00008302307,0.000009919097,0.00002770125,0.002025965,0.00002116621,0.001673311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006857148,"threshold_uncertainty_score":0.002293944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01896565408220456,"score_gpt":0.2428053812511034,"score_spread":0.2238397271688989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}