{"id":"W3125639318","doi":"10.21037/apm-20-1455","title":"Combination therapy with methadone and duloxetine for cancer-related pain: a retrospective study","year":2021,"lang":"en","type":"article","venue":"Annals of Palliative Medicine","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; VCU Massey Cancer Center; National Institutes of Health; Virginia Commonwealth University","keywords":"Medicine; Duloxetine; Methadone; Cancer pain; Retrospective cohort study; Cancer; Internal medicine; Oncology; Anesthesia; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001325218,0.0001795131,0.0005981692,0.0001337418,0.0000638497,0.000004799783,0.00004997147,0.00004523219,0.0001194542],"category_scores_gemma":[0.000729903,0.0001201139,0.00004652806,0.0004982317,0.0001402728,0.0000465767,0.00002067079,0.0001248349,4.426764e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002635337,"about_ca_system_score_gemma":0.00005963766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001065281,"about_ca_topic_score_gemma":0.00007911762,"domain_scores_codex":[0.9986126,0.0001832671,0.0003182007,0.0003265929,0.0003708509,0.0001884282],"domain_scores_gemma":[0.99806,0.0002921531,0.000228499,0.0002068019,0.001120282,0.00009229336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001205854,0.00158118,0.9724479,0.0002677657,0.001806417,0.00006127651,0.008824362,0.000001924506,0.001934733,0.002178928,0.002659463,0.007030153],"study_design_scores_gemma":[0.01327472,0.009644535,0.9656408,0.0004987405,0.0002674587,4.369221e-7,0.003945192,0.0004971076,0.002635844,0.001395933,0.002065276,0.0001338876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587807,0.004381225,0.001125728,0.03324632,0.00006756693,0.001735042,0.00000859338,0.00004610995,0.0006086812],"genre_scores_gemma":[0.9922317,0.003743084,0.0004661855,0.001872128,0.00009376219,0.0001403191,0.00005227558,0.0000221911,0.0013783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03345102,"threshold_uncertainty_score":0.4898101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08184360451195705,"score_gpt":0.3845202708250624,"score_spread":0.3026766663131054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}