{"id":"W3125673614","doi":"10.1038/s41586-020-03114-6","title":"Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":303,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Congressionally Directed Medical Research Programs; National Institute of General Medical Sciences; Azrieli Foundation; Associazione Italiana per la Ricerca sul Cancro; Israel Cancer Association; Ministero della Salute; Ministero dell’Istruzione, dell’Università e della Ricerca; DOD Peer Reviewed Cancer Research Program; National Institutes of Health; Fondazione Cariplo","keywords":"Aneuploidy; Mitosis; Cancer cell; Biology; Spindle checkpoint; Cancer; Cell biology; Cancer research; Ploidy; Spindle apparatus; Genetics; Cell; Cell division; Chromosome; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009779249,0.0002401446,0.0003489928,0.0003547198,0.0002210962,0.0005473063,0.0003046333,0.0004509748,0.003232446],"category_scores_gemma":[0.0002359288,0.0002383582,0.0001824998,0.0002768496,0.0002515077,0.0002378481,0.0003530402,0.0007049022,0.0004192364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00033519,"about_ca_system_score_gemma":0.0002746188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001256873,"about_ca_topic_score_gemma":0.001146119,"domain_scores_codex":[0.9998696,0.00001593507,0.00001439718,0.00002868703,0.0000376247,0.00003373885],"domain_scores_gemma":[0.999815,0.00004529043,0.0000538182,0.00003690981,0.00001007226,0.00003882729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001869572,0.00003305289,0.0001531097,0.00001769538,0.000009464801,0.0001068895,0.00001552018,0.0003174916,0.9971264,0.0005206731,0.0000902192,0.001422425],"study_design_scores_gemma":[0.00004956567,0.0004927429,0.005941208,0.00001132734,0.00003205261,0.0007258305,0.00008134612,0.002187444,0.9840209,0.0004765714,0.005967591,0.00001335097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950795,0.0007332957,0.001023277,0.0002179468,0.00005092421,0.00002258059,0.0003862398,0.0001325343,0.002353678],"genre_scores_gemma":[0.9975373,0.0003612604,0.0002009605,0.00003097803,0.000005720749,0.0000102508,0.0001439672,0.00002529487,0.001684339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003232446,"threshold_uncertainty_score":0.01081359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005389339220358215,"score_gpt":0.2465541117708542,"score_spread":0.241164772550496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}