{"id":"W3125735562","doi":"10.1101/2021.01.28.427950","title":"Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Diabetes Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Vasopressin; G protein-coupled receptor; Receptor; Agonist; Ligand (biochemistry); Functional selectivity; G protein; Chemistry; Vasopressin receptor; Biology; Peptide; Cell biology; Biochemistry; Biophysics; Endocrinology; Antagonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986633,0.0002548351,0.0002828481,0.0001188291,0.000179301,0.0005099115,0.0002682761,0.0004806103,0.001325918],"category_scores_gemma":[0.0001866992,0.0001295689,0.0001575558,0.0001910814,0.0004066599,0.0002390474,0.0002543462,0.0003111876,0.0005032163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000307972,"about_ca_system_score_gemma":0.0001764441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005042432,"about_ca_topic_score_gemma":0.0004143399,"domain_scores_codex":[0.9998296,0.00003071085,0.00000710398,0.00003896718,0.00006408722,0.00002939126],"domain_scores_gemma":[0.9999624,0.000009924222,0.000009078111,0.000005379111,0.000005885248,0.000007315123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109245,0.00001512666,0.0004810516,0.00008408745,0.00001482394,0.0002079276,0.00002316879,0.006671675,0.9799912,0.009505404,0.0004868147,0.002409554],"study_design_scores_gemma":[0.00005932181,0.0001448593,0.003182357,0.00001734545,0.00001662858,0.0007571203,0.00008503514,0.1553828,0.8109956,0.009763199,0.01955422,0.00004143764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9090557,0.001764112,0.07827748,0.0006340169,0.0001742226,0.00002976197,0.0007511239,0.00042324,0.008890361],"genre_scores_gemma":[0.982818,0.0005916708,0.008929486,0.00007321752,0.00002386726,0.00001750872,0.0003315696,0.00006021818,0.007154381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325918,"threshold_uncertainty_score":0.004435599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406797646063321,"score_gpt":0.2167729494039366,"score_spread":0.2027049729433034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}