{"id":"W3125756598","doi":"10.1016/j.jpsychires.2021.01.029","title":"Investigating the role of CB1 endocannabinoid transmission in the anti-fear and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation","year":2021,"lang":"en","type":"article","venue":"Journal of Psychiatric Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Institute of Mental Health; National Institutes of Health","keywords":"Ventromedial prefrontal cortex; AM251; Endocannabinoid system; Basolateral amygdala; Psychology; Prefrontal cortex; Fatty acid amide hydrolase; Cannabinoid receptor; Cannabinoid; Anxiolytic; Neuroscience; Amygdala; Stimulation; Elevated plus maze; Extinction (optical mineralogy); Agonist; Anxiety; Chemistry; Medicine; Internal medicine; Receptor; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003587806,0.0001211956,0.0004122714,0.0004796405,0.0001358713,0.00003967587,0.0002838424,0.0001034706,0.00003423088],"category_scores_gemma":[0.001217804,0.00006924478,0.0001772221,0.001318286,0.0003259202,0.00009164287,0.00006790761,0.00115391,5.866779e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007275373,"about_ca_system_score_gemma":0.001012922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125907,"about_ca_topic_score_gemma":0.00002802221,"domain_scores_codex":[0.9957698,0.001035397,0.0007330882,0.0001910673,0.001887584,0.000383044],"domain_scores_gemma":[0.9981129,0.0004953227,0.0002781677,0.0002858182,0.0006296432,0.00019814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007331558,0.0009802766,0.07449525,0.001540782,0.0001373787,0.0002195794,0.008543083,0.0001311532,0.8173032,0.0003641991,0.006877879,0.08867408],"study_design_scores_gemma":[0.003664669,0.002004069,0.9728663,0.0003351693,0.00008296553,0.0003589703,0.003925863,0.002458419,0.009040871,0.001539556,0.003646957,0.0000762055],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729006,0.01473895,0.00006604431,0.01133244,0.0001406165,0.0005942829,0.000002611454,0.000001915507,0.0002225866],"genre_scores_gemma":[0.9981751,0.0008198999,0.0004238085,0.0000834088,0.0003427458,0.000009553465,0.00000350718,0.00001677803,0.0001251533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.898371,"threshold_uncertainty_score":0.501323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323061486174768,"score_gpt":0.3275369259294261,"score_spread":0.3143063110676784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}