{"id":"W3125783850","doi":"10.3390/cells10020210","title":"Berberine Prevents Disease Progression of Nonalcoholic Steatohepatitis through Modulating Multiple Pathways","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"Nonalcoholic fatty liver disease; Steatosis; Fatty liver; Hepatic stellate cell; Fibrosis; Berberine; Steatohepatitis; Cancer research; Downregulation and upregulation; Biology; Inflammation; Medicine; Pharmacology; Internal medicine; Endocrinology; Immunology; Disease; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003085176,0.0001327658,0.0002519213,0.00002010463,0.00004770071,0.000009189093,0.00004090998,0.00003456586,0.0002923378],"category_scores_gemma":[0.00004465239,0.000109675,0.0001608813,0.000113016,0.00003183373,0.00007164236,0.00007799302,0.00005143039,0.0000310756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004555126,"about_ca_system_score_gemma":0.0001276384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004152701,"about_ca_topic_score_gemma":0.000003579131,"domain_scores_codex":[0.9990053,0.00003894366,0.0002311705,0.00026967,0.0002791953,0.0001757457],"domain_scores_gemma":[0.9992111,0.00006003488,0.00009140124,0.0003301901,0.0001036662,0.0002036244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009926944,0.003583689,0.9496517,0.0007050288,0.0002413562,0.0006940402,0.0004890769,0.000068562,0.02773535,0.000126358,0.0004471906,0.01615838],"study_design_scores_gemma":[0.003303434,0.0001811222,0.6067939,0.001173082,0.0004361058,0.000006458759,0.00006026286,0.001038474,0.3853343,0.0002123426,0.001297009,0.0001635086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963471,0.001590559,0.00003466663,0.0001161255,0.0001104614,0.0004442837,0.0001425798,0.00003022781,0.001184026],"genre_scores_gemma":[0.9963172,0.0003502522,0.002478254,0.0001244097,0.00007390716,0.00007670982,0.0002552814,0.0000218823,0.0003020688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3575989,"threshold_uncertainty_score":0.4472418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02953068974354781,"score_gpt":0.289561079201643,"score_spread":0.2600303894580952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}