{"id":"W3125827151","doi":"10.2139/ssrn.3420832","title":"Induction of an Alternative 5’ Leader Enhances Translation of <i>Inpp5e</i> and Resistance to Oncolytic Virus Infection","year":2019,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique; Discovery Centre; Children's Hospital of Eastern Ontario","funders":"","keywords":"Oncolytic virus; Virology; Virus; Translation (biology); Resistance (ecology); Biology; Microbiology; Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005120326,0.0006969503,0.0007053346,0.0003762311,0.0002941329,0.0007554992,0.0004927128,0.0006353214,0.003289427],"category_scores_gemma":[0.0005107766,0.0004189197,0.0006180609,0.0002876198,0.0005599027,0.0003748932,0.0005408667,0.002166142,0.001753411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009458663,"about_ca_system_score_gemma":0.0005727943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008969043,"about_ca_topic_score_gemma":0.001348043,"domain_scores_codex":[0.9992939,0.0001572194,0.0001218154,0.0001350477,0.000125978,0.0001659168],"domain_scores_gemma":[0.9993675,0.0002140234,0.0001279715,0.0001054255,0.00005271733,0.0001322669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001582989,0.00005976644,0.0000622854,0.0000332332,0.000005024046,0.00003729901,0.00002543509,0.00006111647,0.9985439,0.0002122211,0.0001376962,0.0006637088],"study_design_scores_gemma":[0.00001430394,0.0001174566,0.0004932008,0.000004137942,0.000008187079,0.00005831236,0.00001209536,0.0004726131,0.9969247,0.00002236684,0.001867999,0.0000046123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814283,0.0009535829,0.01086159,0.0005323779,0.0002989616,0.0001251541,0.001489284,0.0006380549,0.003672887],"genre_scores_gemma":[0.9756925,0.000316881,0.01337554,0.0002561601,0.00008207507,0.0001092819,0.003181832,0.0004576442,0.006527957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003289427,"threshold_uncertainty_score":0.01100427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321656951196359,"score_gpt":0.2933242061446034,"score_spread":0.2801076366326398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}