{"id":"W3125845294","doi":"10.1101/2021.01.21.427632","title":"Pannexin 1 influences lineage specification of human iPSCs","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Endoderm; Biology; Ectoderm; Mesoderm; Pannexin; Cell biology; Induced pluripotent stem cell; Germ layer; Gene knockout; Paracrine signalling; Lineage (genetic); Cellular differentiation; Genetics; Embryo; Embryonic stem cell; Gene; Embryogenesis; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002567924,0.0001764222,0.0002026105,0.0002291036,0.0001280382,0.0003869921,0.0001569865,0.0002832553,0.001491777],"category_scores_gemma":[0.0001895353,0.0001554117,0.0002130348,0.0001227592,0.0001173006,0.0001659853,0.0002567796,0.0004873377,0.0005312114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001713064,"about_ca_system_score_gemma":0.0001270344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003785549,"about_ca_topic_score_gemma":0.0005262807,"domain_scores_codex":[0.9997677,0.00003711886,0.0000416059,0.00005580583,0.00006362125,0.00003406349],"domain_scores_gemma":[0.999862,0.00004506309,0.00002825546,0.00002057896,0.00002599051,0.00001814556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000044042,0.00001918258,0.0003528435,0.00002973627,0.000004825345,0.00007745552,0.0000439601,0.000124361,0.9971871,0.0001145905,0.00009643043,0.001905567],"study_design_scores_gemma":[0.0000108602,0.0001137522,0.00538826,0.00001635252,0.00002458974,0.0003067362,0.00005249239,0.001805949,0.9841632,0.00006223599,0.008050973,0.000004562538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847724,0.001871547,0.006302113,0.0001151396,0.00005979442,0.0001099249,0.001310939,0.0001393511,0.00531877],"genre_scores_gemma":[0.9886645,0.001056916,0.003199266,0.0001045163,0.00001115775,0.00008945767,0.001866438,0.00006711441,0.004940548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491777,"threshold_uncertainty_score":0.004990518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863853413803508,"score_gpt":0.2459463915502092,"score_spread":0.2273078574121741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}