{"id":"W3125911246","doi":"10.3390/biomedicines9020117","title":"A Peptide-Nucleic Acid Targeting miR-335-5p Enhances Expression of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene with the Possible Involvement of the CFTR Scaffolding Protein NHERF1","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Peptide nucleic acid; microRNA; Messenger RNA; Molecular biology; Scaffold protein; Mutation; Gene; Chemistry; Regulator; Nucleic acid; Cell biology; Biology; Biochemistry; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374791,0.0001859563,0.0002327993,0.000036236,0.0001245155,0.00001242969,0.0002645119,0.00009671316,0.00003900584],"category_scores_gemma":[0.00007294711,0.0001032397,0.0001019537,0.000337678,0.0003557989,0.00001028614,0.00008939603,0.0000517786,4.987775e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001725053,"about_ca_system_score_gemma":0.0001609063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001673172,"about_ca_topic_score_gemma":0.00001777592,"domain_scores_codex":[0.9986357,0.0001255763,0.0003577306,0.0003428629,0.0003325238,0.0002056168],"domain_scores_gemma":[0.9988553,0.00002088014,0.000333677,0.0004984701,0.0002367065,0.00005497834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403871,0.00006326882,0.0004017464,0.0003937464,0.00005881766,0.000001449534,0.0002269374,0.00003307481,0.997911,0.00000839552,0.0005720899,0.00018905],"study_design_scores_gemma":[0.0006334113,0.0001631581,0.002861143,0.0007533982,0.00006762383,0.000006803978,0.0005246567,0.00003593307,0.993564,0.00002252416,0.001237573,0.0001298415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878057,0.01041798,0.0006089563,0.0005180567,0.0000944037,0.0004810912,0.00003629397,0.00000911503,0.00002840692],"genre_scores_gemma":[0.9958761,0.00005901813,0.003469093,0.00005527166,0.0001801963,0.00005174351,0.00007826236,0.00002478242,0.0002055654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035896,"threshold_uncertainty_score":0.4209993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008512375620645468,"score_gpt":0.2238812316855541,"score_spread":0.2153688560649086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}