{"id":"W3125911246","doi":"10.3390/biomedicines9020117","title":"A Peptide-Nucleic Acid Targeting miR-335-5p Enhances Expression of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene with the Possible Involvement of the CFTR Scaffolding Protein NHERF1","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Peptide nucleic acid; microRNA; Messenger RNA; Molecular biology; Scaffold protein; Mutation; Gene; Chemistry; Regulator; Nucleic acid; Cell biology; Biology; Biochemistry; Signal transduction; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001873189,0.0003626708,0.0002223901,0.000157968,0.0001448187,0.000193647,0.0001718456,0.0004284483,0.001244021],"category_scores_gemma":[0.000184912,0.0001208298,0.0002997223,0.00009306247,0.0002289625,0.0001721443,0.0001559322,0.0005850953,0.0004005578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688416,"about_ca_system_score_gemma":0.0001863005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002196537,"about_ca_topic_score_gemma":0.0002534571,"domain_scores_codex":[0.9998411,0.00002872887,0.00001689937,0.00004234372,0.00004803149,0.00002290575],"domain_scores_gemma":[0.9999051,0.00002776884,0.0000323721,0.000006861005,0.000008614061,0.00001928957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005857557,0.00001187299,0.00003383447,0.00003119562,0.000001732137,0.00002243989,0.00000491813,0.00003020124,0.9992581,0.00004896773,0.0000179625,0.0004800712],"study_design_scores_gemma":[0.0000149583,0.0003994454,0.0008275177,0.000004068578,0.00001640155,0.0001852447,0.000008771835,0.0006540052,0.9963905,0.00003294827,0.001462322,0.000003771172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821573,0.001750067,0.01283751,0.0002920447,0.0001409345,0.00009233994,0.0003923638,0.00025463,0.002082746],"genre_scores_gemma":[0.9860877,0.0006823863,0.01098397,0.0001398401,0.00002327569,0.00006453317,0.0003652098,0.00003051234,0.001622529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244021,"threshold_uncertainty_score":0.004161596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008512375620645468,"score_gpt":0.2238812316855541,"score_spread":0.2153688560649086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}