{"id":"W3125972787","doi":"10.1083/jcb.202002075","title":"Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex","year":2020,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Cancer Society; Canada Foundation for Innovation; Government of Ontario; Canadian Institutes of Health Research; Parkinson Canada; Genome Canada; Ontario Genomics; Wellcome Trust","keywords":"Endosome; Phosphatidylinositol; GTPase; Signal transducing adaptor protein; mTORC1; Cell biology; Lysosome; Phenotype; Chemistry; Biology; Phosphorylation; Signal transduction; Biochemistry; PI3K/AKT/mTOR pathway; Enzyme; Gene; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031709,0.00044018,0.0002349189,0.0003177335,0.0001704711,0.0005251239,0.0002766871,0.0003566793,0.001424281],"category_scores_gemma":[0.0001998802,0.0001799295,0.0004307199,0.000166672,0.0002602812,0.0003101098,0.0006774911,0.0003421468,0.0006875414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004268851,"about_ca_system_score_gemma":0.0001893363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000404109,"about_ca_topic_score_gemma":0.000572843,"domain_scores_codex":[0.9997213,0.00005636382,0.00002800194,0.0000518123,0.00007779231,0.00006461941],"domain_scores_gemma":[0.9998732,0.0000162179,0.00003208257,0.00001522444,0.00001295008,0.00005028732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001374241,0.00001116861,0.001672901,0.00004364886,0.00001365551,0.0002312683,0.0000179543,0.0000720771,0.9954224,0.0003114778,0.00005156127,0.002014453],"study_design_scores_gemma":[0.00001609099,0.00009841691,0.02161081,0.00000865762,0.00001989902,0.001032549,0.00005164332,0.001636,0.9723639,0.0001560791,0.003000459,0.000005369142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926814,0.002069535,0.003670001,0.00007968678,0.00001506509,0.00001654022,0.0001709119,0.00009049238,0.00120649],"genre_scores_gemma":[0.9964606,0.000379863,0.001811353,0.00002565727,0.000004698803,0.00001464557,0.0002822563,0.000009463598,0.001011411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424281,"threshold_uncertainty_score":0.004764676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03597540168088732,"score_gpt":0.2528895111059387,"score_spread":0.2169141094250514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}