{"id":"W3125975704","doi":"10.1093/noajnl/vdab013","title":"Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Imperial Experimental Cancer Medicine Centre; Brain Tumour Charity; CHILDREN with CANCER UK; National Institute for Health and Care Research; CRIS Cancer Foundation; Cancer Research UK; NIHR Great Ormond Street Hospital Biomedical Research Centre; Royal Marsden Cancer Charity","keywords":"Liquid biopsy; Biopsy; Digital polymerase chain reaction; Circulating tumor DNA; Glioma; DNA; Sampling (signal processing); Medicine; Pathology; Cell-free fetal DNA; Polymerase chain reaction; Cancer research; Radiology; Oncology; Internal medicine; Gene; Biology; Cancer; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000283218,0.0001780773,0.0004251268,0.0001295056,0.00007739025,0.00001573456,0.00004142132,0.0000750315,0.00002216991],"category_scores_gemma":[0.0004821648,0.0001424592,0.00008277593,0.0002972243,0.00007961192,0.0001472115,0.00004434964,0.0001250376,0.000004419253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005814237,"about_ca_system_score_gemma":0.0000746314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002424223,"about_ca_topic_score_gemma":0.00003780715,"domain_scores_codex":[0.9987657,0.00007017165,0.0003469171,0.0004056619,0.0002074498,0.0002041073],"domain_scores_gemma":[0.9986312,0.0006857503,0.0002400639,0.0001966192,0.0001292884,0.0001170882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001733817,0.002458418,0.7896723,0.00007497962,0.00004160422,0.001303885,0.00004929467,0.00002609681,0.1815634,0.000005017418,0.00001402572,0.02461756],"study_design_scores_gemma":[0.01092028,0.001668018,0.6601576,0.00003462027,0.0003618115,0.0001085992,0.00006367029,0.0001999483,0.3248059,0.0002259213,0.001285434,0.0001681161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975929,0.001116889,0.00003427986,0.0003983326,0.0004276822,0.0002527743,0.0001034186,0.00004424166,0.00002943822],"genre_scores_gemma":[0.9988348,0.000115439,0.0004122734,0.0002595145,0.0001719236,0.0000400493,0.0001422895,0.00002202068,0.000001641681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1432425,"threshold_uncertainty_score":0.5809316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043068592358265,"score_gpt":0.2502478822745665,"score_spread":0.2398171963509838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}