{"id":"W3125976168","doi":"10.1039/d0sc06645a","title":"Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs)","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Nucleic acid; Gene silencing; Chemistry; Molecular biology; Gene; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002262329,0.0001157061,0.0001694946,0.00001828555,0.0000779353,0.00002093437,0.0001791999,0.0001007069,0.000003380488],"category_scores_gemma":[0.0002729464,0.0001004577,0.00005333532,0.0003862771,0.0006955521,0.00001011238,0.0002345295,0.00007951572,5.328332e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002516147,"about_ca_system_score_gemma":0.0001277564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003811906,"about_ca_topic_score_gemma":6.719454e-7,"domain_scores_codex":[0.9988824,0.00003210119,0.0001396346,0.0005030016,0.0002010696,0.0002418278],"domain_scores_gemma":[0.9993389,0.00002096207,0.00007194262,0.000294584,0.0001580583,0.0001155171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002502394,0.00004561563,0.00004343716,0.000005969679,0.000006485319,0.000002449924,0.00001480781,0.000005611038,0.988098,0.000006168006,0.00001572966,0.0117307],"study_design_scores_gemma":[0.0001059481,0.00006441492,0.0002177073,0.00001166128,0.00001222953,0.00001582674,0.00001774377,0.0003543925,0.998935,0.00008751987,0.00004241324,0.0001351711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9300593,0.0001416526,0.06950651,0.00005245941,0.00002020862,0.00004829734,0.00000170287,0.00001736944,0.0001525264],"genre_scores_gemma":[0.9225412,0.0001100613,0.077196,0.00007116807,0.00003620909,0.000002349163,0.000003459329,0.000005985014,0.00003355338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01159553,"threshold_uncertainty_score":0.4096548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111662549146712,"score_gpt":0.2654171806976968,"score_spread":0.2543005552062297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}