{"id":"W3125976168","doi":"10.1039/d0sc06645a","title":"Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs)","year":2021,"lang":"en","type":"article","venue":"Chemical Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Nucleic acid; Gene silencing; Chemistry; Molecular biology; Gene; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002014729,0.0003652801,0.0001811177,0.0001529674,0.0001194808,0.0002102931,0.0001910968,0.000334475,0.0003359906],"category_scores_gemma":[0.0001596197,0.0001670327,0.0002543559,0.0001037562,0.0002119678,0.0001893164,0.0001435511,0.0002376441,0.0002061628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004247376,"about_ca_system_score_gemma":0.0002350556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006810582,"about_ca_topic_score_gemma":0.001023453,"domain_scores_codex":[0.999885,0.00002089135,0.000009292734,0.00003562959,0.000035102,0.00001411777],"domain_scores_gemma":[0.9999297,0.00001182148,0.00002851384,0.000005732687,0.0000104157,0.00001387817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001917776,0.000007564857,0.00003663937,0.00001582458,0.000002126824,0.00001456742,0.000007663743,0.0002132934,0.9985599,0.0001235307,0.000007186867,0.0009924292],"study_design_scores_gemma":[0.00000545248,0.0001226568,0.0002399873,8.876245e-7,0.000003229151,0.00003941797,0.000002301471,0.000831657,0.997851,0.00001490372,0.0008856654,0.000002894824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756523,0.001047951,0.02077714,0.0000977899,0.00002924546,0.0001192406,0.000139667,0.0001388785,0.001997761],"genre_scores_gemma":[0.9743711,0.0005171642,0.02255355,0.00004088103,0.000006542106,0.0000738998,0.0001454164,0.00002383794,0.002267696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006810582,"threshold_uncertainty_score":0.003081739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111662549146712,"score_gpt":0.2654171806976968,"score_spread":0.2543005552062297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}