{"id":"W3126008643","doi":"10.1080/17435390.2021.1872114","title":"Impact of copper oxide particle dissolution on lung epithelial cell toxicity: response characterization using global transcriptional analysis","year":2021,"lang":"en","type":"article","venue":"Nanotoxicology","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"","keywords":"Toxicity; Cytotoxicity; Copper toxicity; Dissolution; Viability assay; Biophysics; Extracellular; In vitro; In vivo; Nanotoxicology; Nanoparticle; Chemistry; Particle size; Particle (ecology); Materials science; Biology; Biochemistry; Nanotechnology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004437738,0.0003956065,0.0005510358,0.0002410289,0.0002399672,0.0006295032,0.0002457321,0.0004463001,0.001161811],"category_scores_gemma":[0.0003803897,0.000203804,0.0004883603,0.0003421109,0.0004651904,0.0002838958,0.0002475315,0.0006469255,0.0002876211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000819123,"about_ca_system_score_gemma":0.0004826873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002996385,"about_ca_topic_score_gemma":0.004315593,"domain_scores_codex":[0.9994594,0.00007776933,0.00002679592,0.0001686609,0.0001778992,0.00008944514],"domain_scores_gemma":[0.999708,0.00007853234,0.00004686332,0.00004688352,0.00009483565,0.00002485903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001780431,0.00003786687,0.0004338822,0.00002911,0.000007039705,0.00000784814,0.00002194725,0.00009853837,0.9981067,0.00002493068,0.00004138242,0.001012761],"study_design_scores_gemma":[0.000006284623,0.0002879849,0.005531985,0.000002580311,0.00001481347,0.00001580873,0.00005193163,0.0009913831,0.9926883,0.00002063791,0.0003825944,0.000005784837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872456,0.0008605871,0.007691282,0.0001663513,0.00005729923,0.0001173826,0.002375167,0.0001513679,0.001335076],"genre_scores_gemma":[0.9892505,0.0006027351,0.004155263,0.0001069824,0.00001281435,0.000194821,0.001641018,0.0000430772,0.003992664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002996385,"threshold_uncertainty_score":0.005957901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183030066113091,"score_gpt":0.30700553197396,"score_spread":0.2851752313128291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}