{"id":"W3126011236","doi":"10.3389/fonc.2020.543648","title":"Management of Primary Central Nervous System Lymphoma Using Intra-Arterial Chemotherapy With Osmotic Blood-Brain Barrier Disruption: Retrospective Analysis of the Sherbrooke Cohort","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Medicine; Retrospective cohort study; Primary central nervous system lymphoma; Carboplatin; Cohort; Febrile neutropenia; Neutropenia; Chemotherapy; Surgery; Methotrexate; Internal medicine; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778132,0.0001883753,0.001088982,0.0001878975,0.00004695188,0.000008100631,0.0001097626,0.0001325219,0.00005205251],"category_scores_gemma":[0.00001117791,0.0001347191,0.0002613342,0.0009635958,0.0002015359,0.00003457064,0.0000558775,0.00006482718,2.256697e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002536129,"about_ca_system_score_gemma":0.0003382371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001238675,"about_ca_topic_score_gemma":0.00009632678,"domain_scores_codex":[0.9983709,0.0001680573,0.0004790945,0.0003808685,0.0003132251,0.0002878525],"domain_scores_gemma":[0.9990543,0.00003799126,0.000250378,0.0004796156,0.00009946066,0.00007822472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007018453,0.001329441,0.9630523,0.0002874462,0.01020446,0.0008628043,0.0005634023,0.0003922748,0.0008820178,0.0003230123,0.0002498569,0.02115111],"study_design_scores_gemma":[0.006236904,0.0003847555,0.9814669,0.0003202873,0.006689775,0.0001117441,0.001179339,0.0009460747,0.002274652,0.00002012372,0.0002596468,0.0001097936],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995007,0.0005967722,0.0009468477,0.0003654839,0.000710452,0.0006650457,0.00002983157,0.00001378661,0.001664828],"genre_scores_gemma":[0.9911491,0.0001755573,0.008184568,0.0001925222,0.00006894363,0.00004994718,0.00004066094,0.00002205869,0.0001166811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02104132,"threshold_uncertainty_score":0.663189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006749573126990382,"score_gpt":0.2396104503251086,"score_spread":0.2328608771981183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}