{"id":"W3126091857","doi":"10.20944/preprints201908.0038.v1","title":"STAT3 and STAT5 Activation in Solid Cancers","year":2019,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Saint-Sacrement","funders":"","keywords":"STAT3; Biology; Cancer research; STAT5; Ubiquitin ligase; STAT protein; SOCS6; Suppressor of cytokine signaling 1; Signal transduction; Epigenetics; Tumor suppressor gene; Transcription factor; Cancer; Cell biology; Carcinogenesis; Suppressor; Ubiquitin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000301029,0.000258956,0.0004866125,0.0002844859,0.00003852919,0.00001787996,0.0001165025,0.0002325116,0.0009950805],"category_scores_gemma":[0.000234729,0.0002629127,0.0001043028,0.0001084713,0.00005167856,0.0001010019,0.0005002013,0.001139455,0.0002529455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005888201,"about_ca_system_score_gemma":0.0005663027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00262822,"about_ca_topic_score_gemma":0.0001195177,"domain_scores_codex":[0.9982758,0.00005532918,0.0004423302,0.000711428,0.000246339,0.0002687341],"domain_scores_gemma":[0.9987362,0.00007888403,0.0002315827,0.0006919874,0.0001399506,0.0001214203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003988309,0.0001896044,0.7561746,0.0006605685,0.0001931176,0.00001641156,0.002333833,0.003943108,0.2343081,0.0001319777,0.0002898187,0.001359994],"study_design_scores_gemma":[0.001353252,0.0000902228,0.7739479,0.001757842,0.00009015269,0.00001581026,0.0004332815,0.001913499,0.2104699,0.0005703662,0.008964366,0.0003933865],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871174,0.00005923399,0.0002450253,0.0007168113,0.0005510698,0.0008539323,0.00003344474,0.00007804765,0.01034506],"genre_scores_gemma":[0.9973798,0.000267108,0.0001204849,0.0002949347,0.0001702431,0.0001074235,0.0001252672,0.00004194815,0.001492803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02383823,"threshold_uncertainty_score":0.9999823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1403697252755419,"score_gpt":0.3977820562857622,"score_spread":0.2574123310102203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}