{"id":"W3126115255","doi":"10.20944/preprints201912.0186.v1","title":"Elucidating Role of Ezh2 in Tolerogenic Function of NOD Bone Marrow-Derived Dendritic Cells Expressing Constitutively Active Stat5b.","year":2019,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; CD11c; NOD mice; Cell biology; IRF4; Nod; Dendritic cell; CD80; Immune tolerance; Cancer research; EZH2; CD86; Immunology; Immune system; Autoimmunity; T cell; CD40; Histone; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218866,0.0001802362,0.0001500869,0.000129274,0.00009498643,0.0001731285,0.0001076582,0.0001692895,0.0006140829],"category_scores_gemma":[0.00003863545,0.00008224016,0.0001476486,0.000080778,0.00015947,0.0001819045,0.000124297,0.0003461668,0.0001573192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937881,"about_ca_system_score_gemma":0.0001131469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002560347,"about_ca_topic_score_gemma":0.0005595362,"domain_scores_codex":[0.9999313,0.000009852359,0.000004866,0.00001324185,0.00001744422,0.00002324762],"domain_scores_gemma":[0.9999709,0.000004184851,0.000008422273,0.000002576467,0.000003158765,0.00001075289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067062,0.00001090128,0.0004491645,0.0000296705,0.000002501519,0.00003747935,0.000008157986,0.00003733227,0.9985606,0.00007424408,0.00001071833,0.0006725682],"study_design_scores_gemma":[0.00003062639,0.0002550523,0.01510364,0.000007432006,0.00001943409,0.0002843947,0.00005677522,0.001360642,0.9807429,0.00008771315,0.002047185,0.0000041678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995914,0.001680673,0.001429137,0.00009023299,0.000009046731,0.00001077943,0.0002320156,0.00001483019,0.0006192678],"genre_scores_gemma":[0.9969311,0.00077041,0.0009768065,0.000053099,0.000006702911,0.00001463847,0.0003547028,0.000005733741,0.0008867758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006140829,"threshold_uncertainty_score":0.002054274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04135003497817277,"score_gpt":0.3116384430680662,"score_spread":0.2702884080898935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}