{"id":"W3126144109","doi":"10.22541/au.160952242.21038379/v1","title":"Allergenic components of the mRNA-1273 vaccine for COVID-19: possible involvement of polyethylene glycol and IgG-mediated complement activation","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Vaccination; Medicine; Immunology; Polyethylene glycol; Immunogenicity; PEG ratio; Complement system; Chemistry; Virology; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002606701,0.0004552946,0.000207268,0.0002249253,0.00009401062,0.0002329176,0.0002265711,0.0005608532,0.002052171],"category_scores_gemma":[0.0001828371,0.0001160047,0.0002924825,0.00007853736,0.0001579144,0.0001984344,0.0001465468,0.000314369,0.0003543435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003110491,"about_ca_system_score_gemma":0.0002046998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005605835,"about_ca_topic_score_gemma":0.0003466632,"domain_scores_codex":[0.9998534,0.0000356709,0.000007523842,0.00002094675,0.00003958969,0.00004295978],"domain_scores_gemma":[0.9999266,0.00001476317,0.00002485863,0.000006022373,0.00001269853,0.00001502911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001529199,0.0003687726,0.006054027,0.0006046157,0.00006192787,0.001702211,0.00006753339,0.0001741159,0.9742838,0.0006120164,0.0003392179,0.01420262],"study_design_scores_gemma":[0.0002931047,0.005540444,0.05738925,0.0001297973,0.0002449575,0.007975873,0.0001426316,0.003858033,0.9099501,0.0007435863,0.01371092,0.00002137396],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888869,0.00586263,0.002199102,0.0001857306,0.00006011014,0.000229472,0.0001852934,0.00003584579,0.00235481],"genre_scores_gemma":[0.9967909,0.00100361,0.0006365917,0.0001202286,0.00001825116,0.00003792335,0.0002534697,0.000005452124,0.001133515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052171,"threshold_uncertainty_score":0.006865144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07633915066156695,"score_gpt":0.3370315003589066,"score_spread":0.2606923496973396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}