{"id":"W3126149304","doi":"10.1212/nxg.0000000000000557","title":"Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes","year":2021,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institutes of Health; Assistance publique-Hôpitaux de Paris; Fondation de France; National Cancer Institute; Landspítali Háskólasjúkrahús; Bundesministerium für Bildung und Forschung; University of Glasgow; Parkinson's UK; National Institute on Aging; National Institute for Health and Care Research; Multiple System Atrophy Coalition; Biogen; Huffington Foundation; Agence Nationale de la Recherche; Sol Goldman Charitable Trust; Canada First Research Excellence Fund; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; Deutsche Forschungsgemeinschaft; McGill University; Demensförbundet; Center for Individualized Medicine, Mayo Clinic; H. Lundbeck A/S; Burroughs Wellcome Fund; Lewy Body Dementia Association; University College London; Wellcome Trust; University of Dundee; Helsingin Yliopisto; U.S. Department of Defense; Itä-Suomen Yliopisto; Little Family Foundation; Parkinson Vereniging; Michael J. Fox Foundation for Parkinson's Research; Mayo Clinic; U.S. Department of Health and Human Services; Helsingin ja Uudenmaan Sairaanhoitopiiri; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Genome-wide association study; Confidence interval; Odds ratio; Logistic regression; Internal medicine; Disease; Genetic model; Meta-analysis; Medicine; Genetics; Biology; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141234,0.0001670067,0.000669237,0.00008436445,0.00008368217,0.00001640354,0.00006883091,0.000101686,0.0002658656],"category_scores_gemma":[0.0004859219,0.0001325425,0.0007342129,0.000274715,0.00002032644,0.00001198785,0.00004845516,0.0001251263,0.00002066572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001554212,"about_ca_system_score_gemma":0.0000499231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003266077,"about_ca_topic_score_gemma":0.00004851397,"domain_scores_codex":[0.9985272,0.000216199,0.0002498824,0.000517492,0.0002189472,0.0002703025],"domain_scores_gemma":[0.9987195,0.0004349005,0.0001149327,0.000393242,0.0001764113,0.0001610817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000365497,0.001275351,0.9649175,0.0000076617,0.0326139,0.0003058954,0.0000210634,0.0001995741,0.000120807,0.000003546672,0.0001309531,0.0000382571],"study_design_scores_gemma":[0.001033101,0.001363484,0.8382533,4.992068e-8,0.1516347,5.223341e-7,0.000005381772,0.0001218892,0.00004500939,0.0004415819,0.007029364,0.0000715835],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866005,0.00254431,0.0001850379,0.009602115,0.00008959702,0.0007688042,0.00008170999,0.00003653742,0.00009139354],"genre_scores_gemma":[0.9839403,0.0001800463,0.0001931385,0.01398411,0.00004586748,0.0001984389,0.0001046067,0.00002012242,0.001333365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1266641,"threshold_uncertainty_score":0.5404925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05722509165551663,"score_gpt":0.301017137276883,"score_spread":0.2437920456213664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}