{"id":"W3126149304","doi":"10.1212/nxg.0000000000000557","title":"Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes","year":2021,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Medical Research Council; National Institutes of Health; Assistance publique-Hôpitaux de Paris; Fondation de France; National Cancer Institute; Landspítali Háskólasjúkrahús; Bundesministerium für Bildung und Forschung; University of Glasgow; Parkinson's UK; National Institute on Aging; National Institute for Health and Care Research; Multiple System Atrophy Coalition; Biogen; Huffington Foundation; Agence Nationale de la Recherche; Sol Goldman Charitable Trust; Canada First Research Excellence Fund; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; Deutsche Forschungsgemeinschaft; McGill University; Demensförbundet; Center for Individualized Medicine, Mayo Clinic; H. Lundbeck A/S; Burroughs Wellcome Fund; Lewy Body Dementia Association; University College London; Wellcome Trust; University of Dundee; Helsingin Yliopisto; U.S. Department of Defense; Itä-Suomen Yliopisto; Little Family Foundation; Parkinson Vereniging; Michael J. Fox Foundation for Parkinson's Research; Mayo Clinic; U.S. Department of Health and Human Services; Helsingin ja Uudenmaan Sairaanhoitopiiri; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Genome-wide association study; Confidence interval; Odds ratio; Logistic regression; Internal medicine; Disease; Genetic model; Meta-analysis; Medicine; Genetics; Biology; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008097012,0.002430123,0.005834299,0.003082791,0.0009982326,0.002218218,0.001684008,0.001918065,0.004187156],"category_scores_gemma":[0.01438023,0.001045492,0.0326945,0.004995542,0.000450433,0.0009829988,0.001370414,0.002382912,0.0003784082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008216646,"about_ca_system_score_gemma":0.001349047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01179931,"about_ca_topic_score_gemma":0.0148217,"domain_scores_codex":[0.9931341,0.00303791,0.001006908,0.001988779,0.0004730523,0.0003591006],"domain_scores_gemma":[0.9916599,0.005449933,0.0008841298,0.00124031,0.0005405082,0.0002252323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004248686,0.00002853244,0.1165698,0.007280153,0.8583134,0.0003658466,0.00006006817,0.00175663,0.001064864,0.0002895559,0.00281706,0.007205386],"study_design_scores_gemma":[0.00101618,0.0002208983,0.06013946,0.0007860078,0.9309375,0.000328022,0.00005752824,0.002678919,0.0004095409,0.0009309205,0.002459336,0.00003575589],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2833496,0.6689894,0.02081818,0.003206647,0.002385935,0.0003882304,0.01622445,0.001042619,0.003595069],"genre_scores_gemma":[0.9514665,0.03631784,0.004951782,0.001193839,0.0006361923,0.0004396105,0.00380291,0.0001668987,0.001024415],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01179931,"threshold_uncertainty_score":0.04282159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05722509165551663,"score_gpt":0.301017137276883,"score_spread":0.2437920456213664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}