{"id":"W3126149784","doi":"10.1016/j.cbpb.2021.110573","title":"Freezing stress adaptations: Critical elements to activate Nrf2 related antioxidant defense in liver and skeletal muscle of the freeze tolerant wood frogs","year":2021,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; Mental Health Research Canada; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Skeletal muscle; Oxidative stress; Antioxidant; Catalase; Biology; SOD2; KEAP1; Superoxide dismutase; Internal medicine; Peroxiredoxin; Endocrinology; Biochemistry; Transcription factor; Cell biology; Andrology; Enzyme; Gene; Peroxidase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007382554,0.0001451864,0.0001758153,0.0002083595,0.000257609,0.0001703655,0.0001361413,0.0001958059,0.00205256],"category_scores_gemma":[0.00006990542,0.0001456642,0.0001895234,0.000091649,0.0001992168,0.0002207867,0.0001738471,0.0002755398,0.0001442475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001149014,"about_ca_system_score_gemma":0.0001074067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101303,"about_ca_topic_score_gemma":0.001982963,"domain_scores_codex":[0.9999707,0.000004533112,0.000002562423,0.000009089057,0.000004073547,0.000009099535],"domain_scores_gemma":[0.999944,0.000004899496,0.00001650339,0.000006275413,0.000009018679,0.00001931451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002374211,0.0000158492,0.003108012,0.00003421351,0.000007714329,0.00006970077,0.00005715964,0.00003867626,0.9953773,0.00009694258,0.0000225656,0.0009344013],"study_design_scores_gemma":[0.00004038508,0.0007749654,0.763048,0.00003240378,0.00006599423,0.0009759205,0.0005965171,0.0006035679,0.2317197,0.0003554597,0.00176717,0.00001987693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987406,0.0002995677,0.000399722,0.00002734336,0.000003971895,0.000004766073,0.0001251481,0.000007737827,0.0003912151],"genre_scores_gemma":[0.9976426,0.0001860029,0.0004762628,0.00004645604,0.000004809086,0.00001485051,0.0002529909,0.000006040746,0.001370041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205256,"threshold_uncertainty_score":0.006866455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662413420036518,"score_gpt":0.2808203411437232,"score_spread":0.264196206943358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}