{"id":"W3126168703","doi":"10.1016/j.jbc.2021.100350","title":"Binding of calcium and magnesium to human cardiac troponin C","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Simon Fraser University","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Actin; Biophysics; Tropomyosin; Chemistry; Isothermal titration calorimetry; Binding site; Troponin; Cardiac muscle; Troponin C; Calcium; Actinin; Crystallography; Biochemistry; Biology; Anatomy; Internal medicine; Medicine; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003003548,0.0003257701,0.0002439273,0.0002557327,0.0004932692,0.0002598203,0.0005110279,0.0006049013,0.004319997],"category_scores_gemma":[0.0008081857,0.0002110257,0.0003132973,0.0002605506,0.0002607693,0.0001298551,0.0003135306,0.000494517,0.0005913625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006715127,"about_ca_system_score_gemma":0.0004491047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004142469,"about_ca_topic_score_gemma":0.004754214,"domain_scores_codex":[0.9997179,0.000059903,0.00001137585,0.0000775127,0.00005298716,0.00008028278],"domain_scores_gemma":[0.9997805,0.00007388246,0.00003463274,0.00002294043,0.00002680174,0.00006118585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001443346,0.0001027332,0.001229642,0.0002144798,0.0000495665,0.0004048665,0.00009260737,0.0001593184,0.9917611,0.0007794914,0.0008856611,0.002877202],"study_design_scores_gemma":[0.0004641248,0.001273801,0.04140408,0.00006996709,0.00009672591,0.003433517,0.0001872688,0.003117785,0.9257209,0.0006877408,0.02350185,0.00004222379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740331,0.007610587,0.002351596,0.0008111575,0.0002675758,0.0000961872,0.0003494435,0.00003859713,0.01444179],"genre_scores_gemma":[0.9846265,0.002182422,0.001869203,0.0002498252,0.00007141569,0.00005046794,0.001358177,0.00001193881,0.009580143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004319997,"threshold_uncertainty_score":0.0144518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04098150322419177,"score_gpt":0.3094400017304798,"score_spread":0.2684584985062881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}