{"id":"W3126194737","doi":"10.1139/cjpp-2020-0662","title":"Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; Southern Medical University; National Science Foundation","keywords":"Pulmonary fibrosis; CTGF; Fibrosis; Autophagy; Angiotensin II; NOX4; Pirfenidone; Bleomycin; Pharmacology; Receptor; Renin–angiotensin system; Fibroblast; Medicine; Chemistry; Idiopathic pulmonary fibrosis; Oxidative stress; Endocrinology; Internal medicine; In vitro; Lung; Growth factor; Apoptosis; Biochemistry; NADPH oxidase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264572,0.0002344148,0.0004237157,0.0001917256,0.0001614991,0.000184506,0.0001867396,0.0002683592,0.0008258243],"category_scores_gemma":[0.00006981855,0.00007850808,0.0002809005,0.00007469051,0.000242249,0.0002435231,0.0001582647,0.0006351389,0.0001150383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187354,"about_ca_system_score_gemma":0.0003279515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005702818,"about_ca_topic_score_gemma":0.001309275,"domain_scores_codex":[0.9999039,0.00002504921,0.000007173325,0.00001233405,0.00001744374,0.00003408558],"domain_scores_gemma":[0.9999579,0.000004082721,0.00001485016,0.000003638981,0.000005255051,0.00001423293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001531248,0.0002725454,0.0002767742,0.0001748565,0.00001947243,0.0001366804,0.00002930882,0.0001230849,0.9918793,0.0002284312,0.0001821669,0.005146106],"study_design_scores_gemma":[0.0002746545,0.003689791,0.005588311,0.00002286711,0.00005831559,0.0004312955,0.00008272767,0.001667894,0.9835237,0.0001698096,0.004479334,0.00001136064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906844,0.005277749,0.001742982,0.0004124719,0.00006964247,0.0000361186,0.0001166967,0.0001228961,0.00153704],"genre_scores_gemma":[0.9954938,0.001664918,0.00112075,0.00008549522,0.00002008249,0.00003337165,0.0001031604,0.000005559575,0.00147299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008258243,"threshold_uncertainty_score":0.002762675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008244981071282426,"score_gpt":0.242268766405826,"score_spread":0.2340237853345436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}