{"id":"W3126256293","doi":"10.1016/j.str.2021.01.001","title":"Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding","year":2021,"lang":"en","type":"article","venue":"Structure","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Axoneme; Tubulin; Biology; Plasma protein binding; Crystal structure; Crystallography; Biophysics; Cell biology; Microtubule; Chemistry; Biochemistry; Gene; Flagellum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003707041,0.0001298109,0.0001874847,0.0000654105,0.00003467951,0.00001602036,0.00007286301,0.0001629418,0.00003444864],"category_scores_gemma":[0.00001438411,0.0001134778,0.000022972,0.0001244328,0.00004710452,0.000008049203,0.00006667696,0.0001227475,6.798962e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001424708,"about_ca_system_score_gemma":0.00003108492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002059197,"about_ca_topic_score_gemma":0.004664529,"domain_scores_codex":[0.9992766,0.00004637439,0.0002175839,0.0002195834,0.00008021884,0.0001596532],"domain_scores_gemma":[0.9996544,0.000003946754,0.00008910579,0.0001749683,0.00004755591,0.00003004724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000293219,0.000008515659,0.0265415,0.00007706162,0.00001310456,0.000006135068,0.0002185491,0.0000751773,0.9725028,0.0002000088,0.00004774044,0.0002800838],"study_design_scores_gemma":[0.001348859,0.0001398198,0.09440564,0.00008801438,0.00001461651,0.0001002029,0.000834853,0.00007532947,0.9012659,0.001096004,0.0003908666,0.0002399343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991602,0.0003138244,0.00008299604,0.0000355628,0.00001536223,0.0001269679,0.0001918538,0.000002870449,0.00007034664],"genre_scores_gemma":[0.9976584,0.00004782993,0.001282711,0.00005286681,0.00003926112,0.000001488328,0.0008821863,0.000012488,0.00002271458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07123695,"threshold_uncertainty_score":0.4627492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007282775713213858,"score_gpt":0.2353650690683726,"score_spread":0.2280822933551587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}