{"id":"W3126256293","doi":"10.1016/j.str.2021.01.001","title":"Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding","year":2021,"lang":"en","type":"article","venue":"Structure","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Axoneme; Tubulin; Biology; Plasma protein binding; Crystal structure; Crystallography; Biophysics; Cell biology; Microtubule; Chemistry; Biochemistry; Gene; Flagellum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205403,0.000422279,0.0007083011,0.0002655957,0.0006204838,0.0008200481,0.0009185396,0.0007684255,0.002722],"category_scores_gemma":[0.0003076378,0.0003110695,0.0002667196,0.0004165191,0.0002883358,0.0004129772,0.0002547379,0.001375896,0.0007101761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001921708,"about_ca_system_score_gemma":0.0008368627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007279405,"about_ca_topic_score_gemma":0.01315347,"domain_scores_codex":[0.9998878,0.000009834413,0.000006748292,0.00002786163,0.00004107963,0.00002657617],"domain_scores_gemma":[0.9998924,0.00002458665,0.00002514154,0.000007067812,0.00001476566,0.00003601393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002162697,0.0006791134,0.009595535,0.0007583568,0.0003041412,0.00618915,0.0005986557,0.005277325,0.9207639,0.006493171,0.02292637,0.02425169],"study_design_scores_gemma":[0.0005931365,0.0003831631,0.06305826,0.0001312002,0.0002324866,0.007750466,0.0006620534,0.04764038,0.7910654,0.001301403,0.0870254,0.0001566644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824372,0.005232241,0.00230749,0.001573481,0.0001657595,0.00004839117,0.00283458,0.0004000325,0.005000831],"genre_scores_gemma":[0.9682323,0.003482443,0.009559796,0.000759043,0.00004439354,0.00006482178,0.009717636,0.0001744878,0.007964902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007279405,"threshold_uncertainty_score":0.01447403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007282775713213858,"score_gpt":0.2353650690683726,"score_spread":0.2280822933551587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}