{"id":"W3126266366","doi":"10.1093/carcin/bgab009","title":"Pirh2, an E3 ligase, regulates the AIP4–p73 regulatory pathway by modulating AIP4 expression and ubiquitination","year":2021,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"Ubiquitin ligase; Ectopic expression; Ubiquitin; Small interfering RNA; Downregulation and upregulation; Cell biology; Regulator; Biology; Effector; Ubiquitin-Protein Ligases; Cancer research; Genetics; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000377358,0.000283159,0.0003563382,0.0000931735,0.0003411746,0.00006564474,0.0001230567,0.0002432854,0.00008671355],"category_scores_gemma":[0.0002225296,0.000233389,0.00013413,0.0003519703,0.0001357295,0.0001629442,0.0001417086,0.0002304037,0.000007404217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001521999,"about_ca_system_score_gemma":0.0002210786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004385912,"about_ca_topic_score_gemma":0.00001587231,"domain_scores_codex":[0.997838,0.0002225619,0.0003890163,0.0006717978,0.0005018638,0.0003768107],"domain_scores_gemma":[0.9982423,0.00009114862,0.000163008,0.0009216147,0.0003226782,0.0002592577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005070723,0.000072633,0.002625708,0.00009892871,0.00003938075,0.00007883107,0.0005838558,0.00008760634,0.974542,0.0001266328,0.001492157,0.02020158],"study_design_scores_gemma":[0.001066448,0.0001268591,0.03424775,0.0002763263,0.0001435827,0.000209652,0.0005625276,0.001852141,0.9584865,0.0001391577,0.002632803,0.0002562843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852009,0.01227256,0.000279735,0.0007868413,0.0001900226,0.0003966398,0.00003885779,0.0001383043,0.0006960648],"genre_scores_gemma":[0.9970675,0.0001953675,0.0006336142,0.0006946519,0.000277183,0.00005680785,0.000232691,0.0000857277,0.0007564215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03162204,"threshold_uncertainty_score":0.9517326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255560650427905,"score_gpt":0.2346439617119994,"score_spread":0.2220883552077204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}