{"id":"W3126266366","doi":"10.1093/carcin/bgab009","title":"Pirh2, an E3 ligase, regulates the AIP4–p73 regulatory pathway by modulating AIP4 expression and ubiquitination","year":2021,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"Ubiquitin ligase; Ectopic expression; Ubiquitin; Small interfering RNA; Downregulation and upregulation; Cell biology; Regulator; Biology; Effector; Ubiquitin-Protein Ligases; Cancer research; Genetics; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073647,0.0004054414,0.0002590172,0.0002829792,0.0002020786,0.0003186466,0.0002747282,0.0002352172,0.001908105],"category_scores_gemma":[0.00009114533,0.000111882,0.0002342926,0.0001793355,0.0002851322,0.0002213254,0.0002957546,0.0003866207,0.0004893445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003579729,"about_ca_system_score_gemma":0.0002062794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002252625,"about_ca_topic_score_gemma":0.0003079996,"domain_scores_codex":[0.9998938,0.00001635373,0.000006294134,0.00002693914,0.00003018883,0.00002639004],"domain_scores_gemma":[0.9999517,0.000005643923,0.00001341675,0.000007458766,0.000005710594,0.00001602466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001104489,0.00002565437,0.0003310149,0.00005366519,0.000008554642,0.0001382415,0.000006127269,0.00007519659,0.9961019,0.0002258475,0.0001431592,0.002780226],"study_design_scores_gemma":[0.00003028808,0.0001289699,0.00415733,0.0000024636,0.00001531391,0.0003536534,0.00002029569,0.001601602,0.9878543,0.000124928,0.005704658,0.000006138673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652806,0.004944741,0.01769168,0.0002969431,0.0001393868,0.00009398528,0.0010523,0.0008410466,0.009659356],"genre_scores_gemma":[0.985863,0.001004321,0.005111062,0.00008993367,0.0000285266,0.00005528633,0.0009075674,0.000048438,0.0068919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001908105,"threshold_uncertainty_score":0.006383181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255560650427905,"score_gpt":0.2346439617119994,"score_spread":0.2220883552077204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}