{"id":"W3126308011","doi":"10.1093/hmg/ddab017","title":"Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"FP7 People: Marie-Curie Actions; National Institutes of Health; Universitair Medisch Centrum Groningen; National Institute of Diabetes and Digestive and Kidney Diseases; Tehran University of Medical Sciences and Health Services; National Research Foundation of Korea; Korea Health Industry Development Institute; National Research Foundation; Exzellenzclusters Entzündungsforschung; Crohn's and Colitis Foundation; Ministry of Education, Culture, Sports, Science and Technology; Deutsche Forschungsgemeinschaft; European Commission; California Department of Fish and Game","keywords":"Human leukocyte antigen; Allele; Biology; Linkage disequilibrium; Ulcerative colitis; Immunology; Haplotype; Locus (genetics); Genetics; Inflammatory bowel disease; Disease; Allele frequency; Genetic association; Population; Antigen; Gene; Genotype; Medicine; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002291132,0.0002650283,0.0006103344,0.0001709844,0.0006494056,0.00003088433,0.0004489871,0.000337789,0.0002347651],"category_scores_gemma":[0.00008856348,0.0002496314,0.0007307632,0.0005367242,0.0003835704,0.00002891231,0.0001238676,0.00030596,0.00001278192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008476071,"about_ca_system_score_gemma":0.0001603549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005634928,"about_ca_topic_score_gemma":0.000513523,"domain_scores_codex":[0.997313,0.0009918833,0.0006187554,0.000539899,0.00009563381,0.0004408797],"domain_scores_gemma":[0.9981431,0.0001600434,0.0003650211,0.0008709009,0.0004169438,0.00004403362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005893491,0.0002335061,0.002796912,0.00001968235,0.00191264,0.00001420399,0.0006515108,0.0001460168,0.9872508,0.00581105,0.0008316333,0.0002731231],"study_design_scores_gemma":[0.001211485,0.0001019691,0.4719075,0.00002736016,0.001482098,0.00000591146,0.0001133932,0.00001438266,0.5190938,0.001250209,0.00451964,0.0002722937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899725,0.005095316,0.002749954,0.0003722591,0.0002033222,0.0005262402,0.0008118752,0.00003410039,0.0002344044],"genre_scores_gemma":[0.9929149,0.0004269244,0.0001312402,0.0004125973,0.00002689954,0.00004734685,0.001948805,0.00003635687,0.004054894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4691106,"threshold_uncertainty_score":0.9999956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03966704483210168,"score_gpt":0.2837839836377156,"score_spread":0.2441169388056139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}