{"id":"W3126338693","doi":"10.20944/preprints202012.0452.v1","title":"An Update on Self-Amplifying mRNA Vaccine Development","year":2020,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"","keywords":"Vector (molecular biology); Computational biology; Messenger RNA; Biology; Computer science; Virology; Immunology; Genetics; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003066191,0.0004866722,0.0003829206,0.0000842816,0.0001160378,0.00003782132,0.001015442,0.0004810604,0.0002417588],"category_scores_gemma":[0.0001057082,0.0005040191,0.0001791763,0.00006451887,0.00001841197,0.000004318426,0.001873849,0.0006113526,0.001602628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006807091,"about_ca_system_score_gemma":0.0003187251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003075413,"about_ca_topic_score_gemma":0.00002096811,"domain_scores_codex":[0.9972075,0.000113401,0.0005118552,0.001516197,0.0002546036,0.0003964737],"domain_scores_gemma":[0.9978439,0.000007558506,0.00024761,0.001450622,0.0001943543,0.0002559723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000541799,0.0005402427,0.185101,0.0002641984,0.0008706157,0.00004059498,0.0007234347,0.001244523,0.8054191,0.00009535629,0.001812998,0.003346123],"study_design_scores_gemma":[0.0003763724,0.0001421039,0.07771596,0.0001030714,0.00004675967,0.000004517531,0.00004603721,0.00008245668,0.8238636,0.0001782548,0.09678509,0.000655808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944753,0.0001558297,0.0003541156,0.0002921514,0.000660273,0.0004044827,0.00002178945,0.0001255809,0.00351047],"genre_scores_gemma":[0.9949232,0.0004839931,0.001316317,0.001376146,0.0007345268,0.0001215996,0.0007219834,0.00006685391,0.0002553917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1073851,"threshold_uncertainty_score":0.9997411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09026055007301298,"score_gpt":0.3414657750612342,"score_spread":0.2512052249882212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}