{"id":"W3126338693","doi":"10.20944/preprints202012.0452.v1","title":"An Update on Self-Amplifying mRNA Vaccine Development","year":2020,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"","keywords":"Vector (molecular biology); Computational biology; Messenger RNA; Biology; Computer science; Virology; Immunology; Genetics; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001531646,0.0006618006,0.0008693372,0.001278614,0.0002447309,0.001430235,0.0008339889,0.001388936,0.007487676],"category_scores_gemma":[0.002057964,0.0005128161,0.0004537239,0.0008951912,0.0004688033,0.002030971,0.0007097884,0.002683399,0.007530787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006011589,"about_ca_system_score_gemma":0.0009671864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003902551,"about_ca_topic_score_gemma":0.0006407361,"domain_scores_codex":[0.9994459,0.00009991826,0.00008870826,0.00008539407,0.0002224259,0.00005759972],"domain_scores_gemma":[0.9988702,0.0006233425,0.00008800146,0.00005394912,0.0002846278,0.00007996318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002239631,0.0001009557,0.0002095006,0.00746356,0.00005734566,0.000328211,0.00009232074,0.0004493389,0.02077583,0.005432756,0.07410529,0.8907609],"study_design_scores_gemma":[0.000009472882,0.0001164465,0.0001161981,0.0004938472,0.00003468088,0.0005667376,0.00001158937,0.00005752071,0.004747394,0.000615446,0.9932209,0.000009738201],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001323227,0.9722363,0.005906191,0.003820753,0.006842506,0.00004797117,0.0002740233,0.0002318243,0.009317329],"genre_scores_gemma":[0.004436716,0.9690531,0.005676956,0.00514801,0.003704272,0.00009167558,0.0007152896,0.0001249741,0.01104888],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007487676,"threshold_uncertainty_score":0.02504879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09026055007301298,"score_gpt":0.3414657750612342,"score_spread":0.2512052249882212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}