{"id":"W3126366424","doi":"10.1128/jvi.02274-20","title":"Reduced Nucleoprotein Availability Impairs Negative-Sense RNA Virus Replication and Promotes Host Recognition","year":2021,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Nucleoprotein; Viral replication; Virology; RNA; RNA virus; Virus; Arenavirus; RNA-dependent RNA polymerase; Lassa virus; Influenza A virus; Viral evolution; Viral entry; Ebola virus; VP40; Genetics; Gene; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572697,0.0002710559,0.0002548059,0.0001439595,0.0001027215,0.0002935919,0.0002313211,0.000303413,0.001691238],"category_scores_gemma":[0.0002252,0.0001379258,0.0001485895,0.00004495971,0.000296796,0.0002074853,0.0001768358,0.0005408556,0.0003089319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653685,"about_ca_system_score_gemma":0.0001427877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003763054,"about_ca_topic_score_gemma":0.0004082384,"domain_scores_codex":[0.9997849,0.00004722644,0.00001906387,0.00004384429,0.00005639585,0.00004858613],"domain_scores_gemma":[0.9997323,0.00007332089,0.00006241706,0.0000322757,0.00002015125,0.000079544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008161669,0.00003301379,0.0001011406,0.00001247609,0.000002696968,0.00002701168,0.000005329766,0.00002791149,0.999227,0.00009479383,0.00002566552,0.0003613263],"study_design_scores_gemma":[0.00001240159,0.0006286554,0.006116349,0.00000788312,0.00001012015,0.0003288748,0.00003923199,0.0009538895,0.9902839,0.0001554627,0.00145741,0.000005813752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951834,0.001021722,0.001986986,0.0001287051,0.00004769916,0.00001484141,0.0001551108,0.00009021453,0.001371257],"genre_scores_gemma":[0.9977788,0.0002773413,0.000627842,0.00004122232,0.00001041638,0.00001259309,0.0001405355,0.00001589083,0.001095241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691238,"threshold_uncertainty_score":0.005657792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04195630492435483,"score_gpt":0.3285808095728802,"score_spread":0.2866245046485253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}