{"id":"W3126405451","doi":"10.3389/fonc.2020.633142","title":"Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Research Institute; Prostate Cancer Foundation","keywords":"Druggability; Topoisomerase; Chemistry; Cancer research; DNA damage; Cell growth; Cancer cell; Cytotoxicity; Docking (animal); Cell cycle checkpoint; Cell cycle; Apoptosis; DNA; Cancer; Biology; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138815,0.0001226266,0.0002783379,0.00005381195,0.00003832785,0.000007999446,0.0001335102,0.0001958084,0.000005137966],"category_scores_gemma":[0.00002666512,0.0001259918,0.0001175154,0.0001204785,0.00007427025,0.000005340803,0.00009317684,0.00007507713,2.921068e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008086934,"about_ca_system_score_gemma":0.0007634129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003060293,"about_ca_topic_score_gemma":0.0001883354,"domain_scores_codex":[0.9991019,0.00003141721,0.0002569056,0.0002935812,0.00007287167,0.0002433174],"domain_scores_gemma":[0.9995089,0.00001478285,0.00009614051,0.0002672631,0.00006868815,0.00004429669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005455782,0.00030739,0.002015921,0.00004421826,0.0002398155,0.0000102212,0.0004157836,0.00005771301,0.8716886,0.0009985568,0.0168705,0.1068057],"study_design_scores_gemma":[0.001466644,0.0006702321,0.0001146319,0.00001247549,0.0000491124,0.000007019368,0.0003612087,0.00007192542,0.642738,0.002277455,0.3520933,0.0001380041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8473881,0.01526278,0.127196,0.002636549,0.005739698,0.0005954443,0.0001212077,0.00001102013,0.001049145],"genre_scores_gemma":[0.9730967,0.002550323,0.01681479,0.001886479,0.0005377612,0.00004609123,0.0001593224,0.00003726386,0.004871242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3352228,"threshold_uncertainty_score":0.5137798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776378547316673,"score_gpt":0.2989784022726334,"score_spread":0.2812146167994667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}