{"id":"W3126405451","doi":"10.3389/fonc.2020.633142","title":"Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Research Institute; Prostate Cancer Foundation","keywords":"Druggability; Topoisomerase; Chemistry; Cancer research; DNA damage; Cell growth; Cancer cell; Cytotoxicity; Docking (animal); Cell cycle checkpoint; Cell cycle; Apoptosis; DNA; Cancer; Biology; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003059927,0.0006846863,0.0007558693,0.0007219421,0.0002097075,0.0009141384,0.0004312657,0.0003681117,0.002860193],"category_scores_gemma":[0.0002109335,0.000292788,0.0004716095,0.0005208848,0.000228201,0.0004862353,0.0004482203,0.0008042905,0.001101619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005923302,"about_ca_system_score_gemma":0.0004100714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003623706,"about_ca_topic_score_gemma":0.001142497,"domain_scores_codex":[0.9998709,0.00001708474,0.000008138087,0.00002658622,0.00004620876,0.00003105014],"domain_scores_gemma":[0.9999237,0.000009044793,0.00001471619,0.000004603426,0.00001704063,0.00003091286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005041186,0.0005056034,0.001018543,0.001200702,0.0001361008,0.0007672381,0.00009609882,0.004702625,0.8821856,0.006192517,0.003533947,0.09915687],"study_design_scores_gemma":[0.001314548,0.006443401,0.004884703,0.0004150366,0.0004460952,0.002825641,0.0001329062,0.01038719,0.7817192,0.004410482,0.1869189,0.0001018118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7511823,0.1378105,0.05849639,0.002555067,0.0006133986,0.001759158,0.004421387,0.001522145,0.04163956],"genre_scores_gemma":[0.8759891,0.07697577,0.02899566,0.001027379,0.000160033,0.0003955569,0.003318243,0.00009306064,0.01304522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002860193,"threshold_uncertainty_score":0.009568274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776378547316673,"score_gpt":0.2989784022726334,"score_spread":0.2812146167994667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}