{"id":"W3126439695","doi":"10.1158/0008-5472.can-20-2489","title":"Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"National Institute of Neurological Disorders and Stroke; Innovative Medicines Initiative; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Wellcome Trust; Novartis Pharma; Ontario Genomics Institute; China Scholarship Council; National Institutes of Health; Ontario Genomics; Florida Department of Health; Mayo Clinic; Pfizer; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA","keywords":"SOX2; Reprogramming; Biology; Transcriptome; Transcription factor; Cancer research; Tumor microenvironment; Immune system; Immunology; Stem cell; Cell biology; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007519125,0.0001992179,0.0001730042,0.000215708,0.0000996743,0.0002503218,0.00006466573,0.00008821918,0.0008334399],"category_scores_gemma":[0.00005406061,0.00009896418,0.000226465,0.0001460429,0.0001163324,0.00009662509,0.0001531067,0.0002867146,0.0002022337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761852,"about_ca_system_score_gemma":0.0001739679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005108512,"about_ca_topic_score_gemma":0.0007387017,"domain_scores_codex":[0.9999105,0.000008951004,0.00000942868,0.00002033899,0.00002779064,0.00002303773],"domain_scores_gemma":[0.9999465,0.000006288477,0.00001610644,0.000005956355,0.000008396387,0.00001678204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002453437,0.000005862815,0.0003372061,0.00001026942,0.000001984561,0.00002140593,0.000007533153,0.00001949025,0.9989783,0.00003212118,0.0000119568,0.0005493761],"study_design_scores_gemma":[0.000008967091,0.0001182352,0.01724783,0.000005026116,0.00001860101,0.0001744714,0.00005302634,0.000714329,0.9792219,0.00004538408,0.002389045,0.000003183769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944987,0.0009035977,0.00236705,0.00004538735,0.00001947753,0.00002408096,0.000600678,0.00006801108,0.001473099],"genre_scores_gemma":[0.9934863,0.0006329452,0.001933932,0.0000857483,0.00001010576,0.00003372734,0.001114958,0.00002323271,0.002679012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008334399,"threshold_uncertainty_score":0.002788186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05354059156191435,"score_gpt":0.3556553722922861,"score_spread":0.3021147807303718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}