{"id":"W3126506681","doi":"10.1177/0192623321988841","title":"Review of the Technical, Toxicological, and PKPD Considerations for Conducting Inhalation Toxicity Studies on Biologic Pharmaceuticals—The Outcome of a Cross-Industry Working Group Survey","year":2021,"lang":"en","type":"review","venue":"Toxicologic Pathology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Medicine; Immunogenicity; Adverse effect; Inhalation; Pharmacology; Intensive care medicine; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00315671,0.0007102171,0.001505521,0.004588557,0.0003028888,0.001440529,0.001318245,0.0012002,0.00263654],"category_scores_gemma":[0.003551519,0.0005134735,0.0009488447,0.004954456,0.0004617896,0.00159637,0.0006689461,0.001399961,0.001225208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001199314,"about_ca_system_score_gemma":0.003556372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002203337,"about_ca_topic_score_gemma":0.004044333,"domain_scores_codex":[0.9989291,0.0002518051,0.0002599977,0.00009879559,0.0004172431,0.00004311062],"domain_scores_gemma":[0.9962212,0.002186417,0.0005035228,0.00007852174,0.0008994362,0.0001108264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000842325,0.00009804736,0.0002854722,0.08880326,0.0002509648,0.0002142444,0.000129021,0.0005352127,0.001567567,0.003083732,0.04313778,0.8618104],"study_design_scores_gemma":[0.00001539149,0.0001645329,0.001677452,0.02992913,0.000373826,0.001000513,0.00009200715,0.000108213,0.0005872564,0.0008046782,0.9652223,0.00002470715],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001288939,0.9982383,0.0001737321,0.0003841928,0.000165786,0.00002072134,0.00005428377,0.000006888565,0.0008272592],"genre_scores_gemma":[0.0005058998,0.9985172,0.000337754,0.0002570374,0.00008887907,0.00001713726,0.00005608977,0.000001899732,0.0002181336],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004588557,"threshold_uncertainty_score":0.01669449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6426821028360793,"score_gpt":0.5450163336589116,"score_spread":0.09766576917716774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}