{"id":"W3126515736","doi":"10.1038/s41467-021-21204-5","title":"PRMT5 inhibition disrupts splicing and stemness in glioblastoma","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; St. Michael's Hospital; Toronto Western Hospital; Hotchkiss Brain Institute; Princess Margaret Cancer Centre; University of Calgary; Ontario Institute for Cancer Research; University of Toronto; Université de Sherbrooke; Hospital for Sick Children; Université de Montréal; University Health Network; Institute for Research in Immunology and Cancer; SickKids Foundation; Structural Genomics Consortium","funders":"Mitacs; Sick Kids Foundation; Stand Up To Cancer; Novartis Pharma; Ontario Genomics Institute; Government of Canada; Ontario Institute for Cancer Research; Université de Sherbrooke; Entertainment Industry Foundation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Canada's Michael Smith Genome Sciences Centre; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Hospital for Sick Children; Pfizer; Government of Ontario; American Association for Cancer Research","keywords":"Protein arginine methyltransferase 5; Cancer research; Transcriptome; Stem cell; Biology; Alternative splicing; RNA splicing; Glioma; Cancer stem cell; Gene; Methyltransferase; Bioinformatics; Cell biology; Exon; Genetics; Gene expression; Methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009084375,0.00007109735,0.00007128505,0.00004546142,0.00009015949,0.00002013834,0.0001138715,0.0002600687,0.00000381465],"category_scores_gemma":[0.00007545459,0.00008085611,0.00002510756,0.000225162,0.00005171009,0.000005837907,0.0002429878,0.0002665568,0.000001640155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003008964,"about_ca_system_score_gemma":0.00005926865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009829548,"about_ca_topic_score_gemma":0.003598244,"domain_scores_codex":[0.9994491,0.00008599727,0.0001334196,0.0001778825,0.00006200503,0.00009160446],"domain_scores_gemma":[0.9990603,0.00002143796,0.00004715481,0.0007432484,0.00009881723,0.00002906911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000479138,0.0001393615,0.009355539,0.00002971233,0.00003516524,0.000003269953,0.0002306952,0.000168271,0.9703307,0.003200068,0.001318989,0.01514036],"study_design_scores_gemma":[0.001965992,0.0001451849,0.2096726,0.0002810507,0.00005560439,0.0002182741,0.0005578743,0.002206744,0.6683202,0.0006569986,0.1153306,0.0005888229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982583,0.01426502,0.0001593006,0.001988093,0.00007608938,0.0001249087,0.00001112567,0.00001188926,0.0007805668],"genre_scores_gemma":[0.9974355,0.0009593519,0.001001376,0.0001380741,0.00005384819,0.00002344901,0.0002183549,0.00001149957,0.0001585582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3020104,"threshold_uncertainty_score":0.3297216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007830923628377104,"score_gpt":0.2822932663845977,"score_spread":0.2744623427562206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}