{"id":"W3126527789","doi":"10.1016/j.brainresbull.2021.02.006","title":"Pubertal immune challenge suppresses the hypothalamic-pituitary-gonadal axis in male and female mice","year":2021,"lang":"en","type":"article","venue":"Brain Research Bulletin","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hypothalamic–pituitary–gonadal axis; Internal medicine; Endocrinology; Kisspeptin; Luteinizing hormone; Hypothalamus; Immune system; Hormone; Follicle-stimulating hormone; Hypothalamic–pituitary–adrenal axis; Lipopolysaccharide; Biology; Downregulation and upregulation; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002886172,0.0006550727,0.0004938808,0.001466595,0.0005309633,0.0007596654,0.0005013871,0.0006834174,0.005062315],"category_scores_gemma":[0.0002961697,0.0005042304,0.0004845915,0.0003277867,0.0009944864,0.0005821563,0.000394163,0.002211541,0.001131831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004958341,"about_ca_system_score_gemma":0.0005650885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067503,"about_ca_topic_score_gemma":0.002731056,"domain_scores_codex":[0.9994498,0.00006477978,0.00002364998,0.000135906,0.000126714,0.0001991347],"domain_scores_gemma":[0.9991936,0.00006201612,0.0002470795,0.00007176639,0.0000450033,0.000380561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002786832,0.0005782245,0.00151094,0.0000404858,0.00001737053,0.0001959515,0.0001111232,0.00006037408,0.9907656,0.0003821457,0.0002692697,0.003281617],"study_design_scores_gemma":[0.0003638977,0.003970128,0.06420083,0.00004982646,0.0000938982,0.000659211,0.0006942056,0.0008867364,0.921476,0.0004261336,0.007122801,0.00005624527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940711,0.001379097,0.0009368779,0.0003764145,0.0001266384,0.00002998608,0.001026177,0.0001670165,0.001886583],"genre_scores_gemma":[0.9757809,0.001782407,0.001352998,0.0004115292,0.000109927,0.0001243106,0.001249234,0.0002983905,0.01889025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005062315,"threshold_uncertainty_score":0.01693511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04488913953643663,"score_gpt":0.3208132920048659,"score_spread":0.2759241524684293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}