{"id":"W3126527789","doi":"10.1016/j.brainresbull.2021.02.006","title":"Pubertal immune challenge suppresses the hypothalamic-pituitary-gonadal axis in male and female mice","year":2021,"lang":"en","type":"article","venue":"Brain Research Bulletin","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hypothalamic–pituitary–gonadal axis; Internal medicine; Endocrinology; Kisspeptin; Luteinizing hormone; Hypothalamus; Immune system; Hormone; Follicle-stimulating hormone; Hypothalamic–pituitary–adrenal axis; Lipopolysaccharide; Biology; Downregulation and upregulation; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003303591,0.000262148,0.000524914,0.000260222,0.000246169,0.0000973085,0.0003385867,0.0001611733,0.003126524],"category_scores_gemma":[0.0064994,0.0002043892,0.0001237844,0.0004617417,0.0006534348,0.00007764943,0.0005832215,0.001200372,0.0002805485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001209654,"about_ca_system_score_gemma":0.0003678236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105485,"about_ca_topic_score_gemma":0.0006055316,"domain_scores_codex":[0.9957194,0.0009621271,0.0004373317,0.0009321258,0.0009931155,0.0009558481],"domain_scores_gemma":[0.9956591,0.002574668,0.00005547153,0.001016347,0.0004942484,0.0002002264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002497879,0.002951603,0.03776249,0.001175972,0.00070979,0.009191709,0.007597384,0.00001571005,0.7409676,0.004353341,0.1435942,0.04918228],"study_design_scores_gemma":[0.004721349,0.0005145181,0.3283436,0.0002589202,0.00003527563,0.00222769,0.005977925,0.00007896714,0.01593202,0.0005734943,0.6409372,0.0003989827],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.723514,0.02318365,0.000005310862,0.2387675,0.0000767512,0.0007834182,0.00001736299,0.00002966788,0.01362241],"genre_scores_gemma":[0.9558486,0.001338809,0.0004307086,0.0003476062,0.0003835941,0.0001815031,0.00003335348,0.00005742275,0.04137838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7250356,"threshold_uncertainty_score":0.9977847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04488913953643663,"score_gpt":0.3208132920048659,"score_spread":0.2759241524684293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}