{"id":"W3126538193","doi":"10.1007/s00432-021-03545-2","title":"Personalized oncology and BRAFK601N melanoma: model development, drug discovery, and clinical correlation","year":2021,"lang":"en","type":"article","venue":"Journal of Cancer Research and Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; Ottawa Regional Cancer Foundation; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Cancer Research; Terry Fox Research Institute","keywords":"Melanoma; Medicine; Cancer research; Trametinib; Oncology; Internal medicine; MEK inhibitor; Hematology; Drug development; Drug; Pharmacology; Biology; MAPK/ERK pathway; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002883981,0.0007810065,0.001035695,0.0007023749,0.0003149669,0.002445401,0.0008763373,0.001095373,0.00212191],"category_scores_gemma":[0.004119995,0.0003565627,0.0007155283,0.0007834313,0.0008455164,0.001381561,0.0008611981,0.001896629,0.000371551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002259439,"about_ca_system_score_gemma":0.003088115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002281296,"about_ca_topic_score_gemma":0.003850801,"domain_scores_codex":[0.9988795,0.0006684407,0.00003765331,0.0001644071,0.0001799211,0.00007007093],"domain_scores_gemma":[0.9982608,0.001018817,0.0003127412,0.0001836065,0.0001196411,0.0001045149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007549263,0.005250926,0.1316464,0.00258917,0.002002967,0.002002669,0.0002953286,0.2513608,0.05934063,0.1165879,0.01453844,0.4068354],"study_design_scores_gemma":[0.001514927,0.008659162,0.05423428,0.0005421197,0.001785679,0.004428014,0.0004232796,0.6355785,0.04016067,0.2106458,0.04179701,0.0002306207],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.78062,0.05019576,0.1107096,0.03052145,0.0004617941,0.0007227093,0.003158488,0.0007350311,0.02287526],"genre_scores_gemma":[0.9693416,0.01150363,0.01591643,0.0009142489,0.0001094215,0.0001507371,0.0006540613,0.00002371793,0.001386062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002883981,"threshold_uncertainty_score":0.01639342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1327775375143624,"score_gpt":0.4965402220445008,"score_spread":0.3637626845301384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}