{"id":"W3126552324","doi":"10.1515/tnsci-2021-0009","title":"Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging","year":2021,"lang":"en","type":"article","venue":"Translational Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Dementia; KEGG; Disease; Gene; Alzheimer's disease; Gene expression; Biology; Pathological; Computational biology; Pathogenesis; Bioinformatics; Biomarker; Gene expression profiling; Medicine; Gene ontology; Genetics; Pathology; Immunology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003718357,0.0005303728,0.0005409136,0.001292671,0.0002394591,0.0004783677,0.0001805675,0.0002625808,0.000798859],"category_scores_gemma":[0.0004054993,0.00008558187,0.0003800235,0.001657481,0.0002152472,0.0002721196,0.0002642436,0.0003920063,0.0002081743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002816616,"about_ca_system_score_gemma":0.000421041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005718517,"about_ca_topic_score_gemma":0.0009826701,"domain_scores_codex":[0.9997728,0.00003770712,0.00001986256,0.00008035437,0.00005503033,0.00003410504],"domain_scores_gemma":[0.9997595,0.0000365691,0.0001063638,0.00001624026,0.00004734077,0.00003409889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002394939,0.0004313696,0.308832,0.0019314,0.0009419383,0.001487572,0.0003332921,0.001089595,0.52447,0.002723339,0.006294437,0.14907],"study_design_scores_gemma":[0.00006029634,0.0005541429,0.9153746,0.0001418972,0.0007010165,0.002517835,0.0002629064,0.003148869,0.04645384,0.003804374,0.02691664,0.00006367773],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9077788,0.06578454,0.01090323,0.0007304728,0.0004720161,0.00011546,0.01036418,0.0002611827,0.003590062],"genre_scores_gemma":[0.9653764,0.01260705,0.01255252,0.0005257715,0.0001855753,0.0001170837,0.006682405,0.00002325682,0.001929904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292671,"threshold_uncertainty_score":0.002672434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06076034049111035,"score_gpt":0.3394480944879571,"score_spread":0.2786877539968468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}