{"id":"W3126558437","doi":"10.1021/acs.jmedchem.0c02077","title":"Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"SignalChem (Canada)","funders":"National Cancer Institute","keywords":"Chemistry; Acetazolamide; Carbonic anhydrase; Cytotoxicity; Cell culture; Growth inhibition; Extracellular; Cancer research; Cell growth; Carbonic anhydrase II; Biochemistry; Carbonic anhydrase inhibitor; Pharmacology; Enzyme; Internal medicine; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154436,0.0001470776,0.0001916379,0.0000512974,0.00008390918,0.0001081651,0.0001987699,0.0001733655,0.0008744252],"category_scores_gemma":[0.0001403243,0.0000429106,0.0001138135,0.00005421213,0.0001146243,0.00007643063,0.0000846836,0.0001991385,0.0001827842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236086,"about_ca_system_score_gemma":0.000204909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008179921,"about_ca_topic_score_gemma":0.001180404,"domain_scores_codex":[0.9999287,0.00001602095,0.000005377698,0.000008930907,0.00002875768,0.00001224887],"domain_scores_gemma":[0.9999381,0.00001461013,0.00001558702,0.000006603852,0.0000129107,0.00001212641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005746248,0.00001189861,0.0001265967,0.00002679695,0.000002975529,0.00002645974,0.000003977254,0.00005011747,0.9984842,0.00005945317,0.00003887283,0.001111122],"study_design_scores_gemma":[0.00001838888,0.0003864195,0.003150463,0.000003369822,0.00000958014,0.0002716522,0.000007590999,0.0008403228,0.9932862,0.00001962001,0.002003853,0.000002562638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936489,0.002408736,0.001578327,0.000223722,0.00002342891,0.0000253097,0.0001327813,0.00004491708,0.001913656],"genre_scores_gemma":[0.9970211,0.0007101925,0.001256501,0.00005515901,0.000007994188,0.00001243959,0.0002290708,0.000005754243,0.0007018047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008744252,"threshold_uncertainty_score":0.002925277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115926919539031,"score_gpt":0.2717755059293136,"score_spread":0.2601828139754105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}