{"id":"W3126579609","doi":"10.3390/cancers13040676","title":"Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Transcription factor; Biology; Enhancer; Leucine zipper; Cell biology; Repressor; Basic helix-loop-helix; Cancer research; DNA-binding protein; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003482877,0.001051384,0.001115968,0.001178339,0.0002942516,0.0009219121,0.001014789,0.00115272,0.002639902],"category_scores_gemma":[0.0003322566,0.000199219,0.0002592292,0.001180268,0.0006945275,0.001263755,0.0006204492,0.001674162,0.002628881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008420789,"about_ca_system_score_gemma":0.000808666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000612392,"about_ca_topic_score_gemma":0.0009260742,"domain_scores_codex":[0.9998983,0.00001771086,0.00001432891,0.0000242484,0.00003010869,0.00001530804],"domain_scores_gemma":[0.9998872,0.00004005734,0.00001626439,0.000003872925,0.0000344328,0.00001815431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001509923,0.00004421235,0.000240592,0.007726538,0.00005734427,0.0002972935,0.000080584,0.0003630605,0.004140147,0.01058573,0.0434498,0.9328637],"study_design_scores_gemma":[0.00001290279,0.00004942019,0.0005161327,0.001296494,0.0000417932,0.001163921,0.00005888992,0.00006679355,0.001031677,0.003769663,0.9919786,0.00001358247],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000117168,0.9973119,0.000202006,0.000407028,0.0003578838,0.000003075885,0.00001664194,0.00001039191,0.001573855],"genre_scores_gemma":[0.0009048558,0.9970536,0.0001328314,0.0002802013,0.0002927785,0.000006779716,0.00003499025,0.000002451384,0.00129151],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002639902,"threshold_uncertainty_score":0.008831322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08317360941810785,"score_gpt":0.3576570747812658,"score_spread":0.2744834653631579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}