{"id":"W3126579609","doi":"10.3390/cancers13040676","title":"Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Transcription factor; Biology; Enhancer; Leucine zipper; Cell biology; Repressor; Basic helix-loop-helix; Cancer research; DNA-binding protein; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001255904,0.0003628335,0.0007350176,0.00009311175,0.000073509,0.00006032292,0.0002809614,0.0004154251,0.0001030664],"category_scores_gemma":[0.0002402334,0.0002863593,0.0003896193,0.000199115,0.00003337098,0.000002917735,0.0000848417,0.0001553243,0.00003217259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307861,"about_ca_system_score_gemma":0.0009093016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003834739,"about_ca_topic_score_gemma":0.0002725634,"domain_scores_codex":[0.9982956,0.000125319,0.0004518172,0.0006292607,0.0001980874,0.0002998994],"domain_scores_gemma":[0.9989743,0.00007310321,0.0001652599,0.0004807809,0.00009591672,0.0002106194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001343015,0.00001077403,0.000002052902,0.0008809317,0.00008651059,0.00001877548,0.00005021557,0.00006642836,0.008679275,0.000001682828,0.001078169,0.9891118],"study_design_scores_gemma":[0.0001462456,0.000141209,0.000007604787,0.001435787,0.0001824678,8.935161e-7,0.00001442132,0.00000108759,0.00709856,0.00001222279,0.990588,0.0003714903],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008538674,0.995043,0.002091228,0.00001142352,0.0008441511,0.0005277359,0.0002951743,0.00001217649,0.0003211913],"genre_scores_gemma":[0.0004316552,0.9947784,0.0005694674,0.00008908522,0.0005241427,0.0001796638,0.001238764,0.00006950829,0.002119305],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9895098,"threshold_uncertainty_score":0.9999589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08317360941810785,"score_gpt":0.3576570747812658,"score_spread":0.2744834653631579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}