{"id":"W3126699130","doi":"10.2139/ssrn.3775176","title":"TCF/LEF Regulation of the Topologically Associated Domain <i>ADI</i> Promotes mESCs to Exit the Pluripotent Ground State","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Induced pluripotent stem cell; Cell biology; Domain (mathematical analysis); Ground state; Physics; Chemistry; Biology; Mathematics; Embryonic stem cell; Genetics; Quantum mechanics; Mathematical analysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556449,0.0002973112,0.0002200012,0.0002926102,0.0002501624,0.0007686518,0.0004788027,0.0003593013,0.005344165],"category_scores_gemma":[0.0001684279,0.0001765353,0.0001952985,0.0001989804,0.0005094216,0.0003677888,0.0003563933,0.001434145,0.002153923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008413884,"about_ca_system_score_gemma":0.0003987652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002104859,"about_ca_topic_score_gemma":0.004265143,"domain_scores_codex":[0.9997997,0.00002239568,0.00002234721,0.00006240186,0.00004341674,0.00004989912],"domain_scores_gemma":[0.999793,0.00003617317,0.00005572752,0.00003423324,0.00001571287,0.00006510579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001076031,0.000042139,0.0002222217,0.000030734,0.000004044868,0.00005001253,0.00001635975,0.0001048005,0.9966397,0.0008070471,0.0002765752,0.001698702],"study_design_scores_gemma":[0.00001672323,0.00003271316,0.001906536,0.000003282489,0.000005984306,0.00006071804,0.00002983755,0.00103685,0.9932943,0.00006263468,0.00354591,0.00000444278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783216,0.001012177,0.0080596,0.0003677912,0.0001200022,0.00003863634,0.00184981,0.0007432796,0.009487065],"genre_scores_gemma":[0.9906852,0.0001390274,0.001792036,0.00009925015,0.00000684061,0.0000236846,0.001002513,0.000172487,0.006078908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005344165,"threshold_uncertainty_score":0.017878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008457219457735247,"score_gpt":0.2383446111297513,"score_spread":0.229887391672016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}